Ellagic acid inhibits migration and invasion by prostate cancer cell lines.
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| Abstract |
Polyphenolic compounds from pomegranate fruit extracts (PFEs) have been reported to possess antiproliferative, pro-apoptotic, anti-inflammatory and anti-invasion effects in prostate and other cancers. However, the mechanisms responsible for the inhibition of cancer invasion remain to be clarified. In the present study, we investigated anti-invasive effects of ellagic acid (EA) in androgen-independent human (PC-3) and rat (PLS10) prostate cancer cell lines in vitro. The results indicated that non-toxic concentrations of EA significantly inhibited the motility and invasion of cells examined in migration and invasion assays. The EA treatment slightly decreased secretion of matrix metalloproteinase (MMP)-2 but not MMP-9 from both cell lines. We further found that EA significantly reduced proteolytic activity of collagenase/gelatinase secreted from the PLS-10 cell line. Collagenase IV activity was also concentration-dependently inhibited by EA. These results demonstrated that EA has an ability to inhibit invasive potential of prostate cancer cells through action on protease activity.
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| Authors | Pornsiri Pitchakarn, Teera Chewonarin, Kumiko Ogawa, Shugo Suzuki, Makoto Asamoto, Satoru Takahashi, Tomoyuki Shirai, Pornngarm Limtrakul |
| Journal | Asian Pacific journal of cancer prevention : APJCP (Asian Pac J Cancer Prev) Vol. 14 Issue 5 Pg. 2859-63 ( 2013) ISSN: 2476-762X [Electronic] Thailand |
| PMID | 23803044 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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