Hormone replacement therapy increases the risk of cranial meningioma.

Abstract

AIM:

We investigated the influence of hormone replacement therapy (HRT) use on the risk of meningioma in a population-based setting.

METHODS:

We conducted a nationwide case-control study in Denmark based on population-based administrative and health registries. The study included all female patients aged 55-84 years with a first time diagnosis of meningioma during 2000-2009. The cases were matched on birth year with female population controls. Ever use of HRT since 1995 was defined as ≥2 HRT prescriptions and categorised according to HRT type (oestrogen only, combined oestrogen-progestagen, and progestagen only) and cumulated duration of use (<1, ≥1 to <5, ≥5 to <10, ≥10 years). We used conditional logistic regression to compute odds ratios (ORs), with 95% confidence intervals (CIs), for meningioma associated with HRT use, and adjusting for potential confounders.

RESULTS:

We identified 924 cases and 6122 controls. Ever use of HRT was associated with an increased risk of meningioma (OR, 1.3; 95%CI, 1.1-1.5) compared with non-use (0-1 prescriptions). The risk increased with increasing duration of HRT use, reaching an OR of 1.7 (95% CI, 1.2-2.3) after more than 10 years of use. The risk of meningioma associated with long-term (≥10 years) HRT use was most pronounced for combined oestrogen-progestagen therapy (OR, 2.2; 95% CI, 1.4-3.3), especially when this regimen constituted the sole HRT therapy (OR, 2.7; 95% CI, 0.9-7.5), although the latter estimate was based on small numbers.

CONCLUSIONS:

Long-term HRT use, particularly of combined oestrogen-progestagen therapy, may increase the risk of meningioma.

• Authors: Lene Andersen, Søren Friis, Jesper Hallas, Pernille Ravn, Henrik Daa Schrøder, David Gaist
• Journal: European journal of cancer (Oxford, England : 1990) (Eur J Cancer) Vol. 49 Issue 15 Pg. 3303-10 (Oct 2013) ISSN: 1879-0852 [Electronic] England
• PMID: 23800670 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Ltd. All rights reserved.

Topics

• Aged
• Aged, 80 and over
• Case-Control Studies
• Cohort Studies
• Denmark (epidemiology)
• Female
• Hormone Replacement Therapy (adverse effects, statistics & numerical data)
• Humans
• Meningeal Neoplasms (chemically induced, epidemiology)
• Middle Aged
• Risk Factors
• Spinal Cord Neoplasms (chemically induced, epidemiology)