Abstract | OBJECTIVE: To determine the frequency of the immunohistochemical profiles of a series of high-grade ductal carcinoma in situ of the breast. METHODS: RESULTS: The frequencies of the immunophenotypes of pure ductal carcinoma in situ were the following: luminal A (24/42 cases; 57.1%), luminal B (05/42 cases; 11.9%), HER2 (07/42 cases; 16.7%), basal-like phenotype (00/42 cases; 0%), and "not classified" (06/42 cases; 14.3%). The immunophenotypes of ductal carcinoma in situ associated with invasive carcinoma were the following: luminal A (46/79 cases; 58.2%), luminal B (10/79 cases; 12.7%), HER2 (06/79 cases; 7.6%), basal-like (06/79 cases; 7.6%), and "not classified" (11/79 cases; 13.9%). There was no significant difference in the immunophenotype frequencies between pure ductal carcinoma in situ and ductal carcinoma in situ associated with invasive carcinoma (p>0.05). High agreement was observed in immunophenotypes between both components (kappa=0.867). CONCLUSION:
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Authors | Amanda Arantes Perez, Rafael Malagoli Rocha, Débora Balabram, Átila da Silva Souza, Helenice Gobbi |
Journal | Clinics (Sao Paulo, Brazil)
(Clinics (Sao Paulo))
Vol. 68
Issue 5
Pg. 674-8
(May 2013)
ISSN: 1980-5322 [Electronic] United States |
PMID | 23778408
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Biomarkers, Tumor
- Keratin-5
- Receptors, Estrogen
- ERBB2 protein, human
- ErbB Receptors
- Receptor, ErbB-2
|
Topics |
- Biomarkers, Tumor
(metabolism)
- Breast Neoplasms
(classification, metabolism, pathology)
- Carcinoma, Ductal, Breast
(classification, metabolism, pathology)
- Carcinoma, Intraductal, Noninfiltrating
(classification, metabolism, pathology)
- ErbB Receptors
(metabolism)
- Female
- Humans
- Immunohistochemistry
- Immunophenotyping
- Keratin-5
(metabolism)
- Middle Aged
- Receptor, ErbB-2
(metabolism)
- Receptors, Estrogen
(metabolism)
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