Impact of immediate breast reconstruction on postoperative adjuvant chemotherapy: a single center study.

Abstract

BACKGROUND:

Various studies have indicated a worldwide increase in the number of immediate breast reconstruction surgeries. However, breast reconstruction should not delay or prevent postoperative cancer therapeutics such as adjuvant chemotherapy and radiotherapy. In response to these developments, our team researched the impact of immediate breast reconstruction on postoperative adjuvant chemotherapy.

METHODS:

From April 2006 to March 2011, 116 patients at Saitama Cancer Center underwent postoperative adjuvant chemotherapy following mastectomy with or without immediate breast reconstruction. Fifty patients received postoperative adjuvant chemotherapy following mastectomy with immediate breast reconstruction (IBR group), and 66 patients received the same treatment but without immediate breast reconstruction (non-IBR group). The outcomes were studied retrospectively by chart review. Patients' average age, body mass index, postoperative complication rate, and days to adjuvant chemotherapy were calculated.

RESULTS:

Mean age and body mass index of patients were 47.0 ± 9.0 years, 22.2 ± 3.0 kg/m(2) and 55.5 ± 10.1 years, 23.0 ± 3.6 kg/m(2) in IBR group and non-IBR group, respectively. Postoperative complication rate was 10.0 % in IBR group and 6.1 % in non-IBR group. Days to adjuvant chemotherapy was 61.0 ± 10.5 days in IBR group and 58.0 ± 12.3 days in non-IBR group.

CONCLUSIONS:

Although complication rate and days to adjuvant chemotherapy were slightly increased in IBR group, the delay was not critical to the initiation of adjuvant chemotherapy in these patient groups.

• Authors: Atsumori Hamahata, Kazuyuki Kubo, Hiroyuki Takei, Takashi Saitou, Yuji Hayashi, Hiroshi Matsumoto, Shigenori Nagai, Kenichi Inoue, Masafumi Kurosumi, Takashi Yamaki, Hiroyuki Sakurai
• Journal: Breast cancer (Tokyo, Japan) (Breast Cancer) Vol. 22 Issue 3 Pg. 287-91 (May 2015) ISSN: 1880-4233 [Electronic] Japan
• PMID: 23756827 (Publication Type: Clinical Trial, Journal Article)

Topics

• Antineoplastic Combined Chemotherapy Protocols (therapeutic use)
• Breast Neoplasms (drug therapy, surgery)
• Chemotherapy, Adjuvant
• Combined Modality Therapy
• Female
• Follow-Up Studies
• Humans
• Mammaplasty
• Middle Aged
• Neoplasm Staging
• Postoperative Complications
• Prognosis
• Retrospective Studies
• Time Factors