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Photosensitizer-loaded gold vesicles with strong plasmonic coupling effect for imaging-guided photothermal/photodynamic therapy.

Abstract
A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/photodynamic therapy (PTT/PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.
AuthorsJing Lin, Shouju Wang, Peng Huang, Zhe Wang, Shouhui Chen, Gang Niu, Wanwan Li, Jie He, Daxiang Cui, Guangming Lu, Xiaoyuan Chen, Zhihong Nie
JournalACS nano (ACS Nano) Vol. 7 Issue 6 Pg. 5320-9 (Jun 25 2013) ISSN: 1936-086X [Electronic] United States
PMID23721576 (Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
Chemical References
  • Drug Carriers
  • Photosensitizing Agents
  • Gold
Topics
  • Animals
  • Cell Line, Tumor
  • Cell Survival (drug effects, radiation effects)
  • Cell Transformation, Neoplastic
  • Drug Carriers (chemistry)
  • Female
  • Gold (chemistry)
  • Humans
  • Mammary Neoplasms, Experimental (drug therapy, pathology)
  • Metal Nanoparticles (chemistry)
  • Mice
  • Mice, Nude
  • Molecular Imaging
  • Photochemotherapy (methods)
  • Photosensitizing Agents (chemistry, pharmacology, therapeutic use)

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