Abstract |
A multifunctional theranostic platform based on photosensitizer-loaded plasmonic vesicular assemblies of gold nanoparticles (GNPs) is developed for effective cancer imaging and treatment. The gold vesicles (GVs) composed of a monolayer of assembled GNPs show strong absorbance in the near-infrared (NIR) range of 650-800 nm, as a result of the plasmonic coupling effect between neighboring GNPs in the vesicular membranes. The strong NIR absorption and the capability of encapsulating photosensitizer Ce6 in GVs enable trimodality NIR fluorescence/thermal/photoacoustic imaging-guided synergistic photothermal/ photodynamic therapy (PTT/ PDT) with improved efficacy. The Ce6-loaded GVs (GV-Ce6) have the following characteristics: (i) high Ce6 loading efficiency (up to ~18.4 wt %; (ii) enhanced cellular uptake efficiency of Ce6; (iii) simultaneous trimodality NIR fluorescence/thermal/photoacoustic imaging; (iv) synergistic PTT/ PDT treatment with improved efficacy using single wavelength continuous wave laser irradiation.
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Authors | Jing Lin, Shouju Wang, Peng Huang, Zhe Wang, Shouhui Chen, Gang Niu, Wanwan Li, Jie He, Daxiang Cui, Guangming Lu, Xiaoyuan Chen, Zhihong Nie |
Journal | ACS nano
(ACS Nano)
Vol. 7
Issue 6
Pg. 5320-9
(Jun 25 2013)
ISSN: 1936-086X [Electronic] United States |
PMID | 23721576
(Publication Type: Journal Article, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Carriers
- Photosensitizing Agents
- Gold
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Topics |
- Animals
- Cell Line, Tumor
- Cell Survival
(drug effects, radiation effects)
- Cell Transformation, Neoplastic
- Drug Carriers
(chemistry)
- Female
- Gold
(chemistry)
- Humans
- Mammary Neoplasms, Experimental
(drug therapy, pathology)
- Metal Nanoparticles
(chemistry)
- Mice
- Mice, Nude
- Molecular Imaging
- Photochemotherapy
(methods)
- Photosensitizing Agents
(chemistry, pharmacology, therapeutic use)
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