[The effect of spirobromin and prospidin on acute and chronic inflammation in rats].

Abstract

The effects of new antitumor drugs spirobromin and prospidin on acute (carraghenin-induced rat paw edema) and chronic ("pellet granuloma") inflammation in rats were studied. The drugs were found to exert the anti-inflammatory effect on the model of chronic proliferative inflammation but to produce no significant changes in the degree of the acute inflammatory reaction. Spirobromin is superior to prospidin by the power of the anti-inflammatory effect. The electron microscopic studies showed that spirobromin and prospidin decrease the activity of fibroblasts in the focus of chronic inflammation.

• Authors: R D Siubaev, L F Stebaeva, G Ia Shvarts, V A Chernov
• Journal: Farmakologiia i toksikologiia (Farmakol Toksikol) 1990 Mar-Apr Vol. 53 Issue 2 Pg. 58-60 ISSN: 0014-8318 [Print] Russia (Federation)
• Vernacular Title: Vliianie spirobromina i prospidina na ostroe i khronicheskoe vospalenie u krys.
• PMID: 2369958 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Anti-Inflammatory Agents, Non-Steroidal
• Piperazines
• Spiro Compounds
• Prospidium
• spirobromin
• Carrageenan

Topics

• Animals
• Anti-Inflammatory Agents, Non-Steroidal (therapeutic use)
• Carrageenan
• Drug Evaluation, Preclinical
• Edema (chemically induced, drug therapy, pathology)
• Granuloma, Foreign-Body (drug therapy, etiology, pathology)
• Inflammation (drug therapy, etiology, pathology)
• Male
• Microscopy, Electron
• Piperazines (therapeutic use)
• Prospidium (therapeutic use)
• Rats
• Spiro Compounds (therapeutic use)
• Time Factors