[Immune reactions following excimer laser and femtosecond laser-assisted penetrating keratoplasty].

Abstract

In 10-20 % of conventional keratoplasties immunological graft reactions (TPR) occur, which may lead to endothelial cell loss and irreversible transplant rejection. Beside the optical advantages of non-mechanical excimer laser trephination, it does not seem to have immunological disadvantages (13.9 % TPR in keratoconus, 2.9 % in Fuchs' dystrophy after 3 years). The femtosecond laser-assisted keratoplasty has visual and refractive outcomes similar to conventional trephination. However, the "mushroom-shaped" trephination seems to have immunological disadvantages (21.8 % TPR in keratoconus after 14 months) and "top hat-shaped" keratoplasties seem to have no immunological disadvantages (6.6 % TPR in Fuchs' dystrophy after 14 months).

• Authors: N Szentmáry, S Goebels, M El-Husseiny, A Langenbucher, B Seitz
• Journal: Klinische Monatsblatter fur Augenheilkunde (Klin Monbl Augenheilkd) Vol. 230 Issue 5 Pg. 486-9 (May 2013) ISSN: 1439-3999 [Electronic] Germany
• Vernacular Title: Immunreaktionen nach Femtosekunden- und Excimerlaser-Keratoplastik.
• PMID: 23695844 (Publication Type: English Abstract, Journal Article, Review)
• Copyright: Georg Thieme Verlag KG Stuttgart · New York.

Topics

• Endothelium, Corneal (immunology)
• Graft Rejection (etiology, immunology)
• Humans
• Immune System Diseases (etiology, immunology)
• Keratoplasty, Penetrating (adverse effects)
• Laser Therapy (adverse effects)