Abstract |
Three new ellagitannin monomers, nilotinins M5-M7 (1-3), a dimer, nilotinin D10 (4), and a trimer, nilotinin T1 (5), together with three known dimers, hirtellin D (7) and tamarixinins B (8) and C (9), and a trimer, hirtellin T2 (6), were isolated from Tamarix nilotica dried leaves. The structures of the tannins were elucidated by intensive spectroscopic methods and chemical conversions into known tannins. The new trimer (5) is a unique macrocyclic type whose monomeric units are linked together by an isodehydrodigalloyl and two dehydrodigalloyl moieties. Additionally, dimeric and trimeric macrocyclic-type tannins isolated from T. nilotica in this study were assessed for possible cytotoxic activity against four human tumor cell lines. Tumor-selective cytotoxicities of the tested compounds were higher than those of synthetic and natural potent cytotoxic compounds, including polyphenols, and comparable with those of 5-fluorouracil and melphalan.
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Authors | Mohamed A A Orabi, Shoko Taniguchi, Hiroshi Sakagami, Morio Yoshimura, Takashi Yoshida, Tsutomu Hatano |
Journal | Journal of natural products
(J Nat Prod)
Vol. 76
Issue 5
Pg. 947-56
(May 24 2013)
ISSN: 1520-6025 [Electronic] United States |
PMID | 23675651
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Antineoplastic Agents, Phytogenic
- Hydrolyzable Tannins
- Polyphenols
- Melphalan
- Fluorouracil
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Topics |
- Antineoplastic Agents, Phytogenic
(chemistry, isolation & purification, pharmacology)
- Drug Screening Assays, Antitumor
- Egypt
- Fluorouracil
(pharmacology)
- Humans
- Hydrolyzable Tannins
(chemistry, isolation & purification, pharmacology)
- Melphalan
(pharmacology)
- Molecular Structure
- Nuclear Magnetic Resonance, Biomolecular
- Plant Leaves
(chemistry)
- Polyphenols
(pharmacology)
- Tamaricaceae
(chemistry)
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