Abstract | BACKGROUND: QUESTIONS/PURPOSES: METHODS: Twenty-eight patients with biopsy-proven, deep, high-grade extremity soft tissue sarcomas greater than 5 cm (AJCC stage III) treated with chemotherapy and surgical excision were compared histologically with 47 matched control subjects treated with surgery alone. RESULTS: A pseudocapsule was identifiable in the majority of tumors and consisted of two identifiable layers, each with specific histological characteristics suggesting the biologic processes occurring in these layers are different. The pseudocapsule was more frequently observed in the group treated with chemotherapy and it was more frequently continuous, thicker, and better developed in this group. Chemotherapy decreased the number of tumors with malignant cells identified within and beyond the pseudocapsule. CONCLUSIONS:
Neoadjuvant chemotherapy contributed to the development of a pseudocapsule and decreased the number of tumors with malignant cells identified within and beyond the pseudocapsule. CLINICAL RELEVANCE: LEVEL OF EVIDENCE: Level III, therapeutic study. See Guidelines for Authors for a complete description of levels of evidence.
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Authors | Patrick W O'Donnell, J Carlos Manivel, Edward Y Cheng, Denis R Clohisy |
Journal | Clinical orthopaedics and related research
(Clin Orthop Relat Res)
Vol. 472
Issue 3
Pg. 849-55
(Mar 2014)
ISSN: 1528-1132 [Electronic] United States |
PMID | 23640206
(Publication Type: Comparative Study, Journal Article)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Antineoplastic Combined Chemotherapy Protocols
(therapeutic use)
- Biopsy
- Cell Survival
(drug effects)
- Chemotherapy, Adjuvant
- Doxorubicin
(administration & dosage)
- Female
- Humans
- Ifosfamide
(administration & dosage)
- Male
- Middle Aged
- Neoadjuvant Therapy
- Neoplasm Grading
- Neoplasm Staging
- Retrospective Studies
- Sarcoma
(drug therapy, pathology, surgery)
- Soft Tissue Neoplasms
(drug therapy, pathology, surgery)
- Treatment Outcome
- Tumor Burden
- Young Adult
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