Abstract | BACKGROUND: Data concerning the results of 2nd generation DES in the treatment of unprotected left main coronary artery (ULMCA) stenosis are limited. The aim of this study was to evaluate the efficacy and safety of stenting with everolimus- (EES) with sirolimus-eluting stent (SES) for the treatment of ULMCA stenosis in the "real world" setting. METHODS: RESULTS: Baseline characteristics were similar between the two stent groups. At 1 year, the rate of MACE was comparable between the two groups (7.5% for EES vs. 13.9% for SES, HR: 0.55 [0.26-1.17], p = 0.117). However, after multivariable or propensity score adjustment, the risk of MACE was significantly lower for EES compared with that for SES (multivariable adjusted HR: 0.42 [0.19-0.92], p = 0.030; propensity score-adjusted HR: 0.43 [0.20-0.95], p = 0.037). These results were mainly driven from the numerically lower rate of repeat revascularization in the EES group (2.5% for EES vs. 7.0% for SES, p = 0.096). As for hard endpoint (death or myocardial infarction) and stent thrombosis, no differences were found between the 2 groups. CONCLUSIONS: In a large cohort of patients receiving ULMCA stenting, the MACE rate was numerically lower in the EES compared with that in the SES (statistically significant only after adjustment), which was mainly driven by significantly lower rates of repeat revascularization.
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Authors | Kyung Woo Park, Woo-Hyun Lim, Hyo-Suk Ahn, Si-Hyuck Kang, Jung-Kyu Han, Sang Eun Lee, Jang-Hyun Cho, Hyeon-Cheol Gwon, Sung Yoon Lee, Jae-Young Rhew, Wan Kim, In-Ho Chae, Hyo-Soo Kim |
Journal | International journal of cardiology
(Int J Cardiol)
Vol. 168
Issue 3
Pg. 2738-44
(Oct 03 2013)
ISSN: 1874-1754 [Electronic] Netherlands |
PMID | 23623141
(Publication Type: Comparative Study, Journal Article, Multicenter Study, Observational Study, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
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Topics |
- Coronary Stenosis
(drug therapy, surgery)
- Drug-Eluting Stents
- Everolimus
- Female
- Humans
- Male
- Middle Aged
- Registries
- Sirolimus
(administration & dosage, analogs & derivatives)
- Time Factors
- Treatment Outcome
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