Down-regulation of GRIM-19 is associated with STAT3 overexpression in breast carcinomas.

Abstract

To evaluate the association of gene associated with retinoic-interferon-induced mortality 19 (GRIM-19) with clinicopathologic features as well as its target gene signal transducer and activator of transcription 3 (STAT3) in patients with breast cancer, GRIM-19 and STAT3 expression was measured immunohistochemically in 108 breast samples and by Western blotting in 20 breast cancer tissues and corresponding nontumorous tissues. Expression of GRIM-19 was severely depressed in the carcinomas relative to matched nontumorous tissues (P < .001), and STAT3 was overexpressed in breast cancer tissues (P < .001), conclusions supported by Western blot analysis. Nonexpression of GRIM-19 was significantly associated with lymph node metastasis (P < .001), advanced tumor-node-metastasis stage (P = .02), and triple-negative phenotype (P = .03). Furthermore, down-regulation of GRIM-19 correlated with STAT3 overexpression (r = 0.56; P < .001). Thus, GRIM-19 is suppressed in primary breast carcinomas, with a corresponding increase in STAT3 activity.

• Authors: Tao Zhou, Lan Chao, Guohua Rong, Chenggang Wang, Rong Ma, Xiao Wang
• Journal: Human pathology (Hum Pathol) Vol. 44 Issue 9 Pg. 1773-9 (Sep 2013) ISSN: 1532-8392 [Electronic] United States
• PMID: 23618357 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier Inc. All rights reserved.

Chemical References

• Apoptosis Regulatory Proteins
• Biomarkers, Tumor
• Receptors, Estrogen
• Receptors, Progesterone
• STAT3 Transcription Factor
• STAT3 protein, human
• NADH, NADPH Oxidoreductases
• NDUFA13 protein, human
• ERBB2 protein, human
• Receptor, ErbB-2

Topics

• Adenocarcinoma (metabolism, pathology)
• Adult
• Aged
• Apoptosis Regulatory Proteins (metabolism)
• Biomarkers, Tumor (metabolism)
• Blotting, Western
• Breast (metabolism, pathology)
• Breast Neoplasms (metabolism, pathology)
• Down-Regulation
• Female
• Humans
• Immunoenzyme Techniques
• Lymph Nodes (pathology)
• Lymphatic Metastasis
• Mastectomy
• Middle Aged
• NADH, NADPH Oxidoreductases (metabolism)
• Neoplasm Staging
• Receptor, ErbB-2 (metabolism)
• Receptors, Estrogen (metabolism)
• Receptors, Progesterone (metabolism)
• STAT3 Transcription Factor (metabolism)