Abstract | OBJECTIVES: Preclinical studies link prenatal nicotine exposure with the development of both ADHD-like phenotype in rodents and blockade of extinction learning in a fear conditioning paradigm, a preclinical model of posttraumatic stress disorder ( PTSD). While these findings suggest that either ADHD, prenatal nicotine exposure, or both could be a risk factor for PTSD, such associations have not been investigated in humans. METHODS: Subjects were ascertained from family-genetic, longitudinal studies of paediatrically and psychiatrically referred children with and without ADHD of both sexes and their siblings followed for 10 years from childhood into adulthood (n = 403 probands; n = 464 siblings; mean age at follow-up of probands and siblings = 22.0 years). All subjects were comprehensively evaluated with structured diagnostic interviews that included questions regarding prenatal use of cigarettes. RESULTS: A total of 12% (104/867) of the sample had been exposed to maternal smoking during pregnancy. There was no interaction effect between maternal smoking during pregnancy and ADHD (z = 0.01, P = 0.99). Maternal smoking during pregnancy and ADHD were independent, significant risk factors for PTSD at the 10-year follow-up (odds ratio = 3.58 [1.35,9.48], z = 2.57, P = 0.01 and odds ratio = 2.23 [1.06,4.69], z = 2.11, P = 0.04, respectively). CONCLUSIONS: These results suggest that both maternal smoking during pregnancy and ADHD are significant predictors of PTSD in humans.
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Authors | Joseph Biederman, Carter Petty, Thomas J Spencer, K Yvonne Woodworth, Pradeep Bhide, Jinmin Zhu, Stephen V Faraone |
Journal | The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry
(World J Biol Psychiatry)
Vol. 15
Issue 1
Pg. 49-55
(Jan 2014)
ISSN: 1814-1412 [Electronic] England |
PMID | 23607442
(Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, Non-U.S. Gov't)
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Chemical References |
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Topics |
- Adolescent
- Adult
- Attention Deficit Disorder with Hyperactivity
(complications)
- Child
- Female
- Follow-Up Studies
- Humans
- Longitudinal Studies
- Male
- Nicotine
(adverse effects)
- Pregnancy
- Prenatal Exposure Delayed Effects
- Referral and Consultation
- Risk Factors
- Smoking
(adverse effects)
- Stress Disorders, Post-Traumatic
(etiology)
- Young Adult
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