Post-procedural hypertension following transcatheter aortic valve implantation: incidence and clinical significance.

Abstract

OBJECTIVES:

This study sought to investigate the blood pressure (BP) response after transcatheter aortic valve implantation (TAVI) and its correlation with short- and mid-term clinical outcomes.

BACKGROUND:

TAVI is an emerging therapy for aortic stenosis patients at high surgical risk. The acute hemodynamic sequelae of this procedure and their clinical relevance are yet unclear.

METHODS:

Consecutive patients who underwent TAVI in a single center were prospectively monitored for BP response during 5 post-procedural days. Clinical parameters, adverse events, and medical treatment were recorded during hospitalization, at 30 days, and at 12 months after the procedure. Patients were divided according to their post-procedural BP response into 2 groups: increased BP and stable BP.

RESULTS:

One hundred and five patients were analyzed. Overall, systolic BP increased immediately after TAVI in the entire cohort by an average of 15 ± 31 mm Hg. This rise was sustained and led to intensification of antihypertensive treatment in 53 patients (51%); these patients were designated as the increased BP group. The increase in systolic BP after TAVI was associated with an increase in stroke volume and cardiac output and was not related to age, baseline cardiac function, or procedural outcomes. Patients with increased BP after TAVI had a significantly better prognosis with fewer adverse events in the hospital (21% vs. 62%, p < 0.01), after 30 days (30% vs. 71%, p < 0.01), and after 12 months (53% vs. 83%, p < 0.01) as compared with patients with stable BP.

CONCLUSIONS:

After TAVI, a substantial number of patients have a significant rise in systolic BP necessitating long-term treatment. This increase in BP is associated with an increase in cardiac output and predicts a better clinical outcome.

• Authors: Gidon Y Perlman, Sasa Loncar, Arthur Pollak, Dan Gilon, Ronny Alcalai, David Planer, Chaim Lotan, Haim D Danenberg
• Journal: JACC. Cardiovascular interventions (JACC Cardiovasc Interv) Vol. 6 Issue 5 Pg. 472-8 (May 2013) ISSN: 1876-7605 [Electronic] United States
• PMID: 23602460 (Publication Type: Journal Article)
• Copyright: Copyright © 2013 American College of Cardiology Foundation. Published by Elsevier Inc. All rights reserved.

Chemical References

• Antihypertensive Agents

Topics

• Aged
• Aged, 80 and over
• Antihypertensive Agents (therapeutic use)
• Aortic Valve Stenosis (diagnosis, mortality, physiopathology, therapy)
• Blood Pressure (drug effects)
• Cardiac Catheterization (adverse effects, mortality)
• Cardiac Output
• Female
• Heart Valve Prosthesis Implantation (adverse effects, methods, mortality)
• Humans
• Hypertension (diagnosis, drug therapy, epidemiology, mortality, physiopathology)
• Incidence
• Israel (epidemiology)
• Kaplan-Meier Estimate
• Logistic Models
• Male
• Prospective Studies
• Risk Factors
• Severity of Illness Index
• Time Factors