Bendamustine salvage therapy for T cell neoplasms.

Abstract

Treatment of relapsed/refractory T cell neoplasms represents an unmet medical need. We recorded, retrospectively, data on 20 consecutive adult patients with T cell neoplasms (8 T cell lymphoma not otherwise specified (T-NOS), 4 angioimmunoblastic (AILT), 3 prolymphocytic leukemia (T-PLL), 3 advance-stage mycosis fungoides (MF) or Sézary syndrome (SS), and 2 T cell large granular lymphocytic leukemia (T-LGL)), treated with bendamustine. Partial (PR) and complete response (CR) rates were reached in nine (45 %) and two (10 %) patients, respectively, including three PR in T-NOS, one CR in AILT, three PR in T-PLL, two PR in MF/SS, and one CR and one PR in T-LGL lymphoma. The 6 months estimated progression free and overall survival was 44 and 67 %, respectively. Grade 3-4 neutropenia and thrombocytopenia were registered in 44 and 25 % of cases. Four patients developed major infectious complications. At a median follow-up of 6 months (range 1-18), 13 patients are alive and 7 patients died all because of lymphoma progression. Bendamustine deserves further investigation in patients with T cell neoplasms.

• Authors: Francesco Zaja, Luca Baldini, Andrés J M Ferreri, Stefano Luminari, Alberto Grossi, Flavia Salvi, Renato Zambello, Maria Goldaniga, Stefano Volpetti, Renato Fanin
• Journal: Annals of hematology (Ann Hematol) Vol. 92 Issue 9 Pg. 1249-54 (Sep 2013) ISSN: 1432-0584 [Electronic] Germany
• PMID: 23592272 (Publication Type: Journal Article, Multicenter Study)

Chemical References

• Antineoplastic Agents, Alkylating
• Nitrogen Mustard Compounds
• Bendamustine Hydrochloride

Topics

• Adult
• Aged
• Aged, 80 and over
• Antineoplastic Agents, Alkylating (therapeutic use)
• Bendamustine Hydrochloride
• Female
• Follow-Up Studies
• Humans
• Leukemia, Large Granular Lymphocytic (diagnosis, drug therapy, epidemiology)
• Lymphoma, T-Cell (diagnosis, drug therapy, epidemiology)
• Male
• Middle Aged
• Nitrogen Mustard Compounds (therapeutic use)
• Retrospective Studies
• Salvage Therapy (methods)