Triggering effect of N-acetylglucosamine on retarded drug release from a lectin-anchored chitosan nanoparticles-in-microparticles system.

Abstract

The aim of this study was to investigate the use of N-acetylglucosamine (NAG) to accelerate drug release from a lectin-modified carrier. A wheat germ agglutinin (WGA)-anchored salmeterol xinafoate (SalX)-loaded nanoparticles-in-microparticles system (NiMS) was prepared with an ionotropic gelation technique combined with a spray drying method. The formulated microparticles were spherical, with diameters ranging mainly from 2 to 8 μm; the drug entrapment efficiency was >70% (w/w), and the loading capacity was approximately 8% (w/w). Drug release from WGA-SalX-NiMS, within the first 4h, was approximately 30% less than that from SalX-NiMS, indicating an effect of lectin-modification to retard drug release from the NiMS. Due to "sugar-lectin" interactions, drug release from WGA-SalX-NiMS was substantially increased after the addition of NAG to the release medium. However, no significant influence of NAG was observed on the drug release profile of SalX-NiMS without WGA anchorage. The characteristics of NAG-WGA interaction may provide valuable insights into the "triggering-effects" of specific sugars on drug release from lectin-anchored carriers. These results suggest that it is possible to control drug release from a lectin-anchored drug delivery system using a specific sugar, and that the designed novel WGA-SalX-NiMS may be a suitable formulation for chronotherapy of asthma.

• Authors: Hui Li, Wen-feng Dong, Jian-yuan Zhou, Xi-ming Xu, Feng-qian Li
• Journal: International journal of pharmaceutics (Int J Pharm) Vol. 449 Issue 1-2 Pg. 37-43 (Jun 05 2013) ISSN: 1873-3476 [Electronic] Netherlands
• PMID: 23587965 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Elsevier B.V. All rights reserved.

Chemical References

• Adrenergic beta-2 Receptor Agonists
• Delayed-Action Preparations
• Drug Carriers
• Wheat Germ Agglutinins
• Salmeterol Xinafoate
• Chitosan
• Albuterol
• Acetylglucosamine

Topics

• Acetylglucosamine (chemistry)
• Adrenergic beta-2 Receptor Agonists (administration & dosage, chemistry)
• Albuterol (administration & dosage, analogs & derivatives, chemistry)
• Chitosan (chemistry)
• Delayed-Action Preparations
• Drug Carriers (chemistry)
• Drug Compounding
• Drug Delivery Systems
• Microspheres
• Nanoparticles
• Particle Size
• Salmeterol Xinafoate
• Time Factors
• Wheat Germ Agglutinins (chemistry)