HOMEPRODUCTSSERVICESCOMPANYCONTACTFAQResearchDictionaryPharmaMobileSign Up FREE or Login

Triggering effect of N-acetylglucosamine on retarded drug release from a lectin-anchored chitosan nanoparticles-in-microparticles system.

Abstract
The aim of this study was to investigate the use of N-acetylglucosamine (NAG) to accelerate drug release from a lectin-modified carrier. A wheat germ agglutinin (WGA)-anchored salmeterol xinafoate (SalX)-loaded nanoparticles-in-microparticles system (NiMS) was prepared with an ionotropic gelation technique combined with a spray drying method. The formulated microparticles were spherical, with diameters ranging mainly from 2 to 8 μm; the drug entrapment efficiency was >70% (w/w), and the loading capacity was approximately 8% (w/w). Drug release from WGA-SalX-NiMS, within the first 4h, was approximately 30% less than that from SalX-NiMS, indicating an effect of lectin-modification to retard drug release from the NiMS. Due to "sugar-lectin" interactions, drug release from WGA-SalX-NiMS was substantially increased after the addition of NAG to the release medium. However, no significant influence of NAG was observed on the drug release profile of SalX-NiMS without WGA anchorage. The characteristics of NAG-WGA interaction may provide valuable insights into the "triggering-effects" of specific sugars on drug release from lectin-anchored carriers. These results suggest that it is possible to control drug release from a lectin-anchored drug delivery system using a specific sugar, and that the designed novel WGA-SalX-NiMS may be a suitable formulation for chronotherapy of asthma.
AuthorsHui Li, Wen-feng Dong, Jian-yuan Zhou, Xi-ming Xu, Feng-qian Li
JournalInternational journal of pharmaceutics (Int J Pharm) Vol. 449 Issue 1-2 Pg. 37-43 (Jun 5 2013) ISSN: 1873-3476 [Electronic] Netherlands
PMID23587965 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
CopyrightCopyright © 2013 Elsevier B.V. All rights reserved.
Chemical References
  • Adrenergic beta-2 Receptor Agonists
  • Delayed-Action Preparations
  • Drug Carriers
  • Wheat Germ Agglutinins
  • Salmeterol Xinafoate
  • Chitosan
  • Albuterol
  • Acetylglucosamine
Topics
  • Acetylglucosamine (chemistry)
  • Adrenergic beta-2 Receptor Agonists (administration & dosage, chemistry)
  • Albuterol (administration & dosage, analogs & derivatives, chemistry)
  • Chitosan (chemistry)
  • Delayed-Action Preparations
  • Drug Carriers (chemistry)
  • Drug Compounding
  • Drug Delivery Systems
  • Microspheres
  • Nanoparticles
  • Particle Size
  • Salmeterol Xinafoate
  • Time Factors
  • Wheat Germ Agglutinins (chemistry)

Join CureHunter, for free Research Interface BASIC access!

Take advantage of free CureHunter research engine access to explore the best drug and treatment options for any disease. Find out why thousands of doctors, pharma researchers and patient activists around the world use CureHunter every day.
Realize the full power of the drug-disease research network!


Choose Username:
Email:
Password:
Verify Password: