Inherently multimodal nanoparticle-driven tracking and real-time delineation of orthotopic prostate tumors and micrometastases.

Abstract

Prostate cancer is the most common cancer among men and the second cause of male cancer-related deaths. There are currently three critical needs in prostate cancer imaging to personalize cancer treatment: (1) accurate intraprostatic imaging for multiple foci and extra-capsular extent; (2) monitoring local and systemic treatment response and predicting recurrence; and (3) more sensitive imaging of occult prostate cancer bone metastases. Recently, our lab developed porphysomes, inherently multimodal, all-organic nanoparticles with flexible and robust radiochemistry. Herein, we validate the first in vivo application of (64)Cu-porphysomes in clinically relevant orthotopic prostate and bony metastatic cancer models. We demonstrate clear multimodal delineation of orthotopic tumors on both the macro- and the microscopic scales (using both PET and fluorescence) and sensitively detected small bony metastases (<2 mm). The unique and multifaceted properties of porphysomes offers a promising all-in-one prostate cancer imaging agent for tumor detection and treatment response/recurrence monitoring using both radionuclide- and photonic-based strategies.

• Authors: Tracy W Liu, Thomas D Macdonald, Cheng S Jin, Joseph M Gold, Robert G Bristow, Brian C Wilson, Gang Zheng
• Journal: ACS nano (ACS Nano) Vol. 7 Issue 5 Pg. 4221-32 (May 28 2013) ISSN: 1936-086X [Electronic] United States
• PMID: 23544841 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Research Support, U.S. Gov't, Non-P.H.S.)

Chemical References

• Copper Radioisotopes
• Lipid Bilayers
• Porphyrins

Topics

• Animals
• Biological Transport
• Cell Line, Tumor
• Copper Radioisotopes
• Humans
• Lipid Bilayers (chemistry)
• Male
• Mice
• Mice, Nude
• Multimodal Imaging
• Nanoparticles (chemistry)
• Neoplasm Micrometastasis (diagnostic imaging)
• Porphyrins (chemistry, metabolism, pharmacokinetics)
• Positron-Emission Tomography
• Prostatic Neoplasms (diagnostic imaging, metabolism, pathology)
• Time Factors
• Tomography, X-Ray Computed