Allogeneic hematopoietic stem cell transplantation may restore gluten tolerance in patients with celiac disease.

Abstract

We report on 2 patients affected by both celiac disease (CD) and β-thalassemia major who underwent successful myeloablative allogeneic hematopoietic stem cell transplantation (HSCT) for the latter condition. After HSCT, the introduction of a gluten-containing diet did not cause the reappearance of clinical, serological, and histological markers of CD in up to 5 years of follow-up. After transplantation, in both patients, dendritic cells and regulatory FoxP3T cells showed a recovery of normal values and no proliferative T-cell response upon gliadin stimulation was found. These data suggest that allogeneic HSCT may lead to induction of gluten tolerance in patients with CD.

• Authors: Rachele Ciccocioppo, Maria Ester Bernardo, Maria Luisa Russo, Alessandro Vanoli, Carla Franco, Myriam Martinetti, Laura Catenacci, Giovanna Giorgiani, Marco Zecca, Antonio Piralla, Fausto Baldanti, Franco Locatelli, Gino Roberto Corazza
• Journal: Journal of pediatric gastroenterology and nutrition (J Pediatr Gastroenterol Nutr) Vol. 56 Issue 4 Pg. 422-7 (Apr 2013) ISSN: 1536-4801 [Electronic] United States
• PMID: 23531481 (Publication Type: Case Reports, Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Glutens

Topics

• Adolescent
• Celiac Disease (complications, immunology, pathology, therapy)
• Child, Preschool
• Female
• Glutens (adverse effects)
• Hematopoietic Stem Cell Transplantation
• Humans
• Immune Tolerance
• Intestinal Mucosa (immunology, pathology)
• Intestines (immunology, pathology)
• Male
• Transplantation, Homologous (immunology)
• Treatment Outcome
• beta-Thalassemia (complications, therapy)