Abstract | PURPOSE: To assess the long-term prognostic value of various types of perfusion defects detected by single-photon emission computed tomography (SPECT) in patients with stable angina. METHODS: RESULTS: During the follow-up, 15 cardiac deaths were recorded, 13 of which were qualified as a sudden cardiac death, 59 acute coronary syndromes, 65 revascularizations and 209 cardiac hospitalizations. The presence of inducible perfusion defects on SPECT was associated with a high risk for occurrence of all analysed end points: sudden cardiac death (HR = 3·96, P = 0·01), cardiac hospitalization (HR = 1·5, P = 0·004), coronary syndrome (HR = 2·33, P = 0·001) and coronary revascularization (HR = 2·76, P = 0·0002), except for the cardiac death (P = 0·27). Resting perfusion defects were highly predictive for cardiac death (HR = 7·45; P = 0·001), but not for other cardiac events (P = NS). The presence of any (inducible or resting) perfusion defects was associated with a high risk of all cardiovascular complications. CONCLUSIONS: In long-term follow-up, SPECT proved highly predictive of cardiac events in patients with suspected or known CAD. In the revascularization era, cardiac death is most accurately related to the presence of resting perfusion defects, but all other cardiac events were better predicted by inducible perfusion defects.
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Authors | Dominika Filipiak-Strzecka, Ewelina Kowalczyk, Piotr Hamala, Nina Kot, Jarosław D Kasprzak, Jacek Kuśmierek, Anna Płachcińska, Piotr Lipiec |
Journal | Clinical physiology and functional imaging
(Clin Physiol Funct Imaging)
Vol. 33
Issue 3
Pg. 218-23
(May 2013)
ISSN: 1475-097X [Electronic] England |
PMID | 23522016
(Publication Type: Journal Article)
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Copyright | © 2013 The Authors Clinical Physiology and Functional Imaging © 2013 Scandinavian Society of Clinical Physiology and Nuclear Medicine. |
Chemical References |
- Radiopharmaceuticals
- Technetium Tc 99m Sestamibi
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Topics |
- Acute Coronary Syndrome
(etiology, physiopathology, therapy)
- Aged
- Angina, Stable
(diagnostic imaging, etiology, mortality, physiopathology, therapy)
- Coronary Artery Disease
(complications, diagnostic imaging, mortality, physiopathology, therapy)
- Coronary Circulation
- Death, Sudden, Cardiac
(etiology)
- Exercise Test
- Female
- Hospitalization
- Humans
- Kaplan-Meier Estimate
- Male
- Middle Aged
- Myocardial Perfusion Imaging
(methods)
- Percutaneous Coronary Intervention
- Predictive Value of Tests
- Prognosis
- Radiopharmaceuticals
- Retrospective Studies
- Risk Assessment
- Risk Factors
- Technetium Tc 99m Sestamibi
- Time Factors
- Tomography, Emission-Computed, Single-Photon
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