Long-term outcome in chronic inflammatory demyelinating polyneuropathy patients treated with intravenous immunoglobulin: a retrospective study.

Abstract

INTRODUCTION:

The objective of this retrospective study was to describe the short- and long-term patterns of IVIg use, safety, and response to treatment in patients with chronic inflammatory demyelinating polyneuropathy (CIDP).

METHODS:

Response to therapy was defined as an improvement of ≥ 1 point on the modified Rankin score at short- and mid-term visits. Patient status at long term was classified as remission, stability, or non-responder.

RESULTS:

Eighty-six patients were included; 60.5% responded at short term and 54.6% at mid-term. At long term, 25.6% of patients were in remission, 65.1% were stable, and 9.3% were non-responders. The only variable associated with remission was a better response during the first 6 months of follow-up.

CONCLUSIONS:

A significant percentage of patients did not require any additional drugs in the long term. This suggests that treatment effect or disease outcome may be stable over time, and treatment regimens should therefore be individualized to avoid overtreatment.

• Authors: Luis Querol, Ricard Rojas-Garcia, Carlos Casasnovas, Maria Jose Sedano, Jose Luis Muñoz-Blanco, Maria Antonia Alberti, Carmen Paradas, Teresa Sevilla, Julio Pardo, Jose Luis Capablo, Rafael Sivera, Antonio Guerrero, Eduardo Gutierrez-Rivas, Isabel Illa
• Journal: Muscle & nerve (Muscle Nerve) Vol. 48 Issue 6 Pg. 870-6 (Dec 2013) ISSN: 1097-4598 [Electronic] United States
• PMID: 23512566 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2013 Wiley Periodicals, Inc.

Chemical References

• Immunoglobulins, Intravenous
• Immunologic Factors

Topics

• Action Potentials (drug effects)
• Adult
• Aged
• Disability Evaluation
• Electric Stimulation
• Female
• Humans
• Immunoglobulins, Intravenous (therapeutic use)
• Immunologic Factors (therapeutic use)
• Longitudinal Studies
• Male
• Middle Aged
• Neural Conduction (drug effects)
• Polyradiculoneuropathy, Chronic Inflammatory Demyelinating (physiopathology, therapy)
• Reaction Time (drug effects, physiology)
• Retrospective Studies
• Treatment Outcome