Hypertonic (3%) saline vs 0.93% saline nebulization for acute viral bronchiolitis: a randomized controlled trial.

Abstract

OBJECTIVE:

To compare the length of hospital stay (primary) and improvement in clinical severity scores (secondary) among children with bronchiolitis nebulized with 3 % hypertonic saline or 0.9% saline.

DESIGN:

Randomized double blind controlled trial.

SETTINGS:

Tertiary care teaching hospital.

PATIENTS:

Hospitalized children (1-24 months) with acute bronchiolitis of moderate severity.

INTERVENTION:

Nebulization of 4 ml of 3% hypertonic saline or 4 mL of 0.9% saline, along with 2.5 mg salbutamol, at 4-hourly intervals till the patient was ready for discharge.

RESULTS:

Baseline characteristics were similar in two groups. Median clinical severity score at admission was 6 (IQR-1) in both the groups. Clinical severity scores monitored afterwards 12-hourly till discharge (132 h) did not show statistically significant differences in 3% and 0.9% saline groups. Mean length of hospital stay (time to reach predefined clinical severity score<3) was 63.93 ± 22.43 h in 3% saline group and 63.51 ± 21.27 h in 0.9% saline group (P=0.878). No adverse events were reported by the parents, caregivers or treating medical attendants in both groups.

CONCLUSION:

Nebulized 3 % saline is not superior to 0.9% saline in infants with clinically diagnosed acute bronchiolitis.

• Authors: Bhagwan S Sharma, Mukesh K Gupta, Shaikh P Rafik
• Journal: Indian pediatrics (Indian Pediatr) Vol. 50 Issue 8 Pg. 743-7 (Aug 2013) ISSN: 0974-7559 [Electronic] India
• PMID: 23502662 (Publication Type: Journal Article, Randomized Controlled Trial)

Chemical References

• Bronchodilator Agents
• Saline Solution, Hypertonic
• Sodium Chloride

Topics

• Acute Disease
• Bronchiolitis, Viral (drug therapy)
• Bronchodilator Agents (administration & dosage)
• Double-Blind Method
• Female
• Humans
• Infant
• Length of Stay
• Male
• Nebulizers and Vaporizers
• Saline Solution, Hypertonic (administration & dosage)
• Sodium Chloride (administration & dosage)