Abstract |
Human gene icb-1 has been originally identified to be involved in differentiation processes of cancer cells. To examine the function of icb-1 in ovarian cancer, we knocked down its expression in three ovarian cancer cell lines and performed microarray-based gene expression profiling with subsequent gene network modeling. Loss of icb-1 expression accelerated proliferation of SK-OV-3, OVCAR-3 and OAW-42 cells and led to upregulation of ovarian cancer biomarkers like KLK10 and CLDN16. Most of the upregulated genes were part of oncogenic pathways regulated by ERĪ± or TNF. Our data suggest that icb-1 gene inhibits growth and progression of ovarian cancer cells.
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Authors | Oliver Treeck, Susanne Schüler, Julia Häring, Maciej Skrzypczak, Claus Lattrich, Olaf Ortmann |
Journal | Cancer letters
(Cancer Lett)
Vol. 335
Issue 2
Pg. 441-6
(Jul 28 2013)
ISSN: 1872-7980 [Electronic] Ireland |
PMID | 23474491
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Ireland Ltd. All rights reserved. |
Chemical References |
- Claudins
- ESR1 protein, human
- Estrogen Receptor alpha
- Intracellular Signaling Peptides and Proteins
- Neoplasm Proteins
- RNA, Small Interfering
- THEMIS2 protein, human
- Tumor Necrosis Factor-alpha
- claudin 16
- KLK10 protein, human
- Kallikreins
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Topics |
- Cell Differentiation
(genetics)
- Cell Line, Tumor
- Cell Proliferation
- Claudins
(biosynthesis)
- Estrogen Receptor alpha
(metabolism)
- Female
- Gene Expression Profiling
- Gene Expression Regulation, Neoplastic
- Humans
- Intracellular Signaling Peptides and Proteins
(genetics, metabolism)
- Kallikreins
(biosynthesis)
- Neoplasm Proteins
(genetics, metabolism)
- Ovarian Neoplasms
(genetics)
- RNA Interference
- RNA, Small Interfering
- Tumor Necrosis Factor-alpha
(metabolism)
- Up-Regulation
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