The frequency of CD127(+) hepatitis C virus (HCV)-specific T cells but not the expression of exhaustion markers predicts the outcome of acute HCV infection.

Abstract

T cells are exhausted and overexpress inhibitory molecules in chronic hepatitis C virus (HCV) infection. It is unclear whether this is the cause or consequence of HCV persistence. By studying serial blood and liver samples of chimpanzees during acute infection, we demonstrate that the early expression of the memory precursor marker CD127 on HCV-specific T cells, but not the expression of inhibitory molecules on those T cells or their ligands in the liver, predicts the outcome of acute infection.

• Authors: Eui-Cheol Shin, Su-Hyung Park, Michelina Nascimbeni, Marian Major, Laura Caggiari, Valli de Re, Stephen M Feinstone, Charles M Rice, Barbara Rehermann
• Journal: Journal of virology (J Virol) Vol. 87 Issue 8 Pg. 4772-7 (Apr 2013) ISSN: 1098-5514 [Electronic] United States
• PMID: 23388706 (Publication Type: Journal Article, Research Support, N.I.H., Extramural, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't)

Chemical References

• Interleukin-7 Receptor alpha Subunit

Topics

• Animals
• Hepacivirus (immunology)
• Hepatitis C (immunology, veterinary)
• Interleukin-7 Receptor alpha Subunit (analysis)
• Pan troglodytes
• Primate Diseases (immunology, virology)
• T-Lymphocyte Subsets (chemistry, immunology)