Synthesis of antioxidants for prevention of age-related macular degeneration.

Abstract

Photooxidation of A2E may be involved in diseases of the macula, and antioxidants could serve as therapeutic agents for these diseases. Inhibitors of A2E photooxidation were prepared by Mannich reaction of the antioxidant quercetin. These compounds contain water-solubilizing amine groups, and several were more potent inhibitors of A2E photooxidation than quercetin.

• Authors: Dharati Joshi, James Field, John Murphy, Mohammed Abdelrahim, Heike Schönherr, Janet R Sparrow, George Ellestad, Koji Nakanishi, Arie Zask
• Journal: Journal of natural products (J Nat Prod) Vol. 76 Issue 3 Pg. 450-4 (Mar 22 2013) ISSN: 1520-6025 [Electronic] United States
• PMID: 23346866 (Publication Type: Journal Article, Research Support, N.I.H., Extramural)

Chemical References

• A2-E (N-retinylidene-N-retinylethanolamine)
• Antioxidants
• Lipofuscin
• Pyridinium Compounds
• Retinoids
• Quercetin

Topics

• Antioxidants (chemical synthesis, chemistry, pharmacology)
• Light
• Lipofuscin (physiology)
• Macular Degeneration (prevention & control)
• Molecular Structure
• Pigment Epithelium of Eye (drug effects)
• Pyridinium Compounds (antagonists & inhibitors, chemical synthesis, chemistry, metabolism, pharmacology)
• Quercetin (pharmacology)
• Retinoids (antagonists & inhibitors, chemical synthesis, chemistry, metabolism, pharmacology)