[Safety and adverse event profiling of pegylated L-asparaginase combined chemotherapy in the treatment of lymphoma].

Abstract

OBJECTIVE:

To analyze the safety and adverse event profiling of pegylated L-asparaginase (PEG-asp) combined chemotherapy in the treatment of lymphoma patients.

METHODS:

The clinical data of 32 lymphoma patients on PEG-asp-based chemotherapy from January 2008 to March 2012 were retrospectively collected and analyzed.

RESULTS:

There were 22 males and 10 females with a median age of 40 years. They were diagnosed as NK/T cell lymphoma (n = 22) and lymphoblastic lymphoma (n = 10). The overall response rate was 71.9% (23/32). And complete remission was 40.6% (13/32) and partial remission 31.3% (10/32). Myelosuppression was the most common adverse event at an incidence of 81.2% (26/32). Other adverse events included a low level of fibrinogen (n = 13, 40.6%), hypoalbuminemia (n = 8, 25%) and hyperlipidemia (n = 9, 28.1%). No instance of anaphylaxis, acute pancreatitis and thrombosis occurred.

CONCLUSION:

PEG-asp is both effective and safe in the treatment of lymphoma and it is well-tolerated.

• Authors: Ling-yan Ping, Wen Zheng, Xiao-pei Wang, Yan Xie, Ning-jing Lin, Mei-feng Tu, Zhi-tao Ying, Chen Zhang, Wei-ping Liu, Li-juan Deng, Jun Zhu, Yu-qin Song
• Journal: Zhonghua yi xue za zhi (Zhonghua Yi Xue Za Zhi) Vol. 92 Issue 46 Pg. 3257-60 (Dec 11 2012) ISSN: 0376-2491 [Print] China
• PMID: 23328509 (Publication Type: English Abstract, Journal Article)

Chemical References

• Asparaginase

Topics

• Adolescent
• Adult
• Antineoplastic Combined Chemotherapy Protocols (adverse effects, therapeutic use)
• Asparaginase (administration & dosage, adverse effects)
• Female
• Humans
• Lymphoma (drug therapy)
• Male
• Middle Aged
• Retrospective Studies
• Treatment Outcome
• Young Adult