Is there still a role for empiric first-line triple therapy using proton pump inhibitor, amoxicillin and clarithromycin for Helicobacter pylori infection in Singapore? Results of a time trend analysis.

Abstract

OBJECTIVE:

This study was aimed to assess whether the efficacy of one-week triple therapy comprising of proton pump inhibitor, amoxicillin and clarithromycin (PPI/A/C) on Helicobacter pylori (H. pylori) infection in Singapore has decreased over the duration from 2005 to 2010.

METHODS:

The clinical data of H. pylori-positive patients treated with one-week PPI/A/C in 2005 and 2010 were reviewed retrospectively using a registry database. The primary endpoint was the difference in treatment success rate.

RESULTS:

A total of 465 patients (n = 174 in 2005 and n = 291 in 2010) were analyzed. In 2010, compared with 2005, the mean age of patients was younger (47 vs 56 years, P < 0.001) and the proportion of foreigners was higher (19.9% vs 5.7%, P < 0.001). The success rate of H. pylori eradication remained similar over the two time periods (90.2% in 2005 vs 88.7% in 2010, P = 0.597). Multinomial logistic regression revealed that mean age, gender, diagnosis and nationality had no impact on the success of H. pylori eradication.

CONCLUSIONS:

From 2005 to 2010, there was no significant decrease in the efficacy of one-week PPI/A/C for the treatment of H. pylori infection. This treatment regime remained an effective first-line therapy for H. pylori infection in Singapore.

• Authors: Tiing Leong Ang, Luokai Wang, Daphne Ang, Priscilla Chiam, Kwong Ming Fock, Eng Kiong Teo
• Journal: Journal of digestive diseases (J Dig Dis) Vol. 14 Issue 2 Pg. 100-4 (Feb 2013) ISSN: 1751-2980 [Electronic] Australia
• PMID: 23253473 (Publication Type: Journal Article)
• Copyright: © 2012 The Authors. Journal of Digestive Diseases © 2012 Chinese Medical Association Shanghai Branch, Chinese Society of Gastroenterology, Renji Hospital Affiliated to Shanghai Jiaotong University School of Medicine and Wiley Publishing Asia Pty Ltd.

Chemical References

• Anti-Bacterial Agents
• Proton Pump Inhibitors
• Amoxicillin
• Clarithromycin

Topics

• Adolescent
• Adult
• Aged
• Aged, 80 and over
• Amoxicillin (therapeutic use)
• Anti-Bacterial Agents (therapeutic use)
• Chronic Disease
• Clarithromycin (therapeutic use)
• Drug Therapy, Combination
• Female
• Gastritis (drug therapy, microbiology)
• Helicobacter Infections (complications, drug therapy, microbiology)
• Helicobacter pylori
• Humans
• Logistic Models
• Male
• Middle Aged
• Peptic Ulcer (drug therapy, microbiology)
• Proton Pump Inhibitors (therapeutic use)
• Retrospective Studies
• Singapore
• Treatment Outcome
• Young Adult