Circulating natriuretic peptide concentrations in hyperthyroid cats.

Abstract

OBJECTIVES:

To assess the influence of thyroid function on natriuretic peptide concentration in hyperthyroid cats before and after treatment.

METHODS:

Serum natriuretic peptide concentration was measured in 61 hyperthyroid cats recruited from first-opinion clinics before and after treatment.

RESULTS:

Following successful treatment, total thyroxine, heart rate, systolic blood pressure and packed cell volume all decreased and bodyweight and creatinine concentrations increased. Furthermore, a significant (P < 0·001) decline in NT-proBNP concentration but not NT-proANP was identified.

CLINICAL SIGNIFICANCE:

Thyroid function has a modest but significant effect on NT-proBNP concentration. Thyroid status should be taken into account when interpreting NT-proBNP concentrations in cats.

• Authors: P Menaut, D J Connolly, A Volk, C Pace, V Luis Fuentes, J Elliott, H Syme
• Journal: The Journal of small animal practice (J Small Anim Pract) Vol. 53 Issue 12 Pg. 673-8 (Dec 2012) ISSN: 1748-5827 [Electronic] England
• PMID: 23146093 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: © 2012 British Small Animal Veterinary Association.

Chemical References

• Antithyroid Agents
• Biomarkers
• Natriuretic Peptides
• Peptide Fragments
• pro-brain natriuretic peptide (1-76)
• Natriuretic Peptide, Brain
• Methimazole
• Thyroxine

Topics

• Animals
• Antithyroid Agents (therapeutic use)
• Biomarkers (blood)
• Blood Pressure (physiology)
• Case-Control Studies
• Cat Diseases (blood, drug therapy)
• Cats (blood)
• Female
• Heart Rate (physiology)
• Hyperthyroidism (blood, drug therapy, veterinary)
• Male
• Methimazole (therapeutic use)
• Natriuretic Peptide, Brain (blood)
• Natriuretic Peptides (blood)
• Peptide Fragments (blood)
• Thyroxine (blood)
• Treatment Outcome