Synovial cell sarcoma of the larynx.

Abstract

Synovial cell sarcoma represents a rare group of cancers, particularly in the head and neck region, that typically affects young individuals and has a male preponderance. Prognosis varies with patient age, site and size of the malignancy, degree of necrosis, high level of mitotic activity, and neurovascular invasion. Complete surgical resection of the tumor via partial or total laryngectomy is the first-line treatment in locally invasive disease. CO(2) lasers have been shown to be useful in controlling localized disease. There is also a role for adjuvant radiotherapy. Ifosfamide-based chemotherapy is most useful for malignant disease.

• Authors: Shruti Jayachandra, Ronald Y Chin, Peter Walshe
• Journal: Hematology/oncology clinics of North America (Hematol Oncol Clin North Am) Vol. 26 Issue 6 Pg. 1209-19 (Dec 2012) ISSN: 1558-1977 [Electronic] United States
• PMID: 23116577 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Topics

• Humans
• Laryngeal Neoplasms (diagnosis, epidemiology, etiology, therapy)
• Sarcoma, Synovial (diagnosis, epidemiology, etiology, therapy)