[Prenatal diethylstilbestrol exposure and breast cancer].

Abstract

Diethylstilbestrol (DES) is a synthetic estrogen prescribed to prevent miscarriages until 1977. Its role in the development of vaginal adenocarcinoma and cervical dysplasia is known and screening codified. Recent cohort studies show that exposure to DES in utero increases breast cancer risk especially after 40 years. This article reports the observation of a breast cancer of exceptional gravity in a patient exposed to DES in utero. It details the risk of breast cancer for "DES daughters" and support possible screening modalities.

• Authors: S Frigo, C Malina, C Mathelin
• Journal: Gynecologie, obstetrique & fertilite (Gynecol Obstet Fertil) Vol. 40 Issue 12 Pg. 784-6 (Dec 2012) ISSN: 1769-6682 [Electronic] France
• Vernacular Title: Exposition anténatale au diéthylstilbestrol et cancer du sein.
• PMID: 23102737 (Publication Type: Case Reports, English Abstract, Journal Article)
• Copyright: Copyright © 2012 Elsevier Masson SAS. All rights reserved.

Chemical References

• Diethylstilbestrol

Topics

• Breast Neoplasms (chemically induced, surgery)
• Carcinoma, Intraductal, Noninfiltrating (chemically induced, surgery)
• Diethylstilbestrol (adverse effects)
• Female
• Humans
• Mastectomy
• Middle Aged
• Pregnancy
• Prenatal Exposure Delayed Effects