Estradiol Congeners (Synthetic Estrogens)

Steroidal compounds related to ESTRADIOL, the major mammalian female sex hormone. Estradiol congeners include important estradiol precursors in the biosynthetic pathways, metabolites, derivatives, and synthetic steroids with estrogenic activities.

Also Known As:

Networked: 117 relevant articles (3 outcomes, 11 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Saeed, Muhammad: 3 articles (01/2010 - 01/2005)
2.	Cavalieri, Ercole L: 3 articles (01/2010 - 04/2002)
3.	Rogan, Eleanor: 3 articles (02/2007 - 01/2005)
4.	Cavalieri, Ercole: 3 articles (02/2007 - 01/2005)
5.	Jordan, V Craig: 2 articles (02/2015 - 04/2013)
6.	Etgen, Anne M: 2 articles (06/2013 - 08/2011)
7.	Zhu, Ya Qin: 2 articles (09/2011 - 04/2011)
8.	Li, Ling Zhi: 2 articles (09/2011 - 04/2011)
9.	Wang, Yue: 2 articles (09/2011 - 04/2011)
10.	Zhang, Yong Liang: 2 articles (09/2011 - 04/2011)

Related Diseases

1.	Thrombosis (Thrombus) 02/12/1975 - " Synthetic estrogens appear to cause significantly greater susceptibility to thrombosis than natural estrogens do. " 01/01/1998 - "Older oral contraceptive (OC) formulations containing high doses of potent synthetic estrogens and progestins are associated with increased risk of thrombosis. " 09/01/1982 - " These results indicated that: 1) CIC.AS could be induced by synthetic estrogens as well as progestogens but not by nonsynthetic hormones; 2) the induction of CIC.AS seemed poorly dose-related; and 3) the induction was not correlated with the duration of use; 4) high CIC.AS levels occurred as soon as 3 weeks after the beginning of synthetic gonadal hormone use in reactive women and persisted throughout treatment and decreased slowly when discontinued; and 5) CIC.AS was detected more frequently (64.7%) in women with thrombosis than in healthy users (32.2%), P0.001. " 02/21/1981 - "The statistically significant correlation found between thrombosis and the presence in the serum of ICs and anti-ethinylestradiol antibodies suggests that an immune mechanism might be responsible for the vascular lesions induced by oral contraceptives containing synthetic estrogens. " 06/01/1990 - "The general use of synthetic estrogens like DC pointed out that near many skilled collateral effects, some others that are showing with a decrease of bile excretion (cholestasis), reversible with their administration interruption; with hepatic cells adenoma that are potentially premalignant and can transform into hepatocellular carcinoma; with vascular complications such as (most frequently in carcinomatousis) "hepatic peliosis" and "thrombosis" of suprahepatic veins (Budd-Chiari's syndrome). "
2.	Neurodegenerative Diseases (Neurodegenerative Disease) 05/01/2005 - "The data support the hypothesis that estrogen analogues may be useful in the treatment of neurodegenerative diseases, particularly in neuroprotection of retinal ganglion cells in ocular pathologies such as glaucoma." 01/15/2010 - "The maximum yield of adducts in the reaction of CAT-Q or NADA-Q with DNA at pH 4 to 7 was at pH 4. When tyrosinase-activated CAT or NADA was reacted with DNA at pH 5 to 8, adduct levels were much higher (10- to 15-fold), and the highest yield was at pH 5. Reaction of catechol quinones of natural and synthetic estrogens, benzene, naphthalene, and dopamine with DNA to form depurinating adducts is a common feature that may lead to initiation of cancer or neurodegenerative disease."
3.	Lung Neoplasms (Lung Cancer) 01/01/1952 - "[Remarkable efficacy of synthetic estrogens in secondary pulmonary cancer of prostatic origin]." 03/01/2005 - "The results showed that both natural and synthetic estrogens decreased the viability and proliferation of A549 lung cancer cells in a dose-dependent manner but at different sensitivities. " 03/01/2005 - "Effect of natural and synthetic estrogens on a549 lung cancer cells: correlation of chemical structures with cytotoxic effects."
4.	Glaucoma 05/01/2005 - "The data support the hypothesis that estrogen analogues may be useful in the treatment of neurodegenerative diseases, particularly in neuroprotection of retinal ganglion cells in ocular pathologies such as glaucoma."
5.	Neoplasms (Cancer) 11/01/1951 - "[Trial treatment of cancers of the larynx and esophagus by synthetic estrogens]." 01/01/2005 - "Implications for a unifying mechanism of tumor initiation by natural and synthetic estrogens." 04/01/2003 - "Prenatal exposure to natural and synthetic estrogens is associated with increases in breast and vaginal tumors in humans as well as uterine tumors in animals. " 09/01/1987 - "Certain of these estrogen analogues inhibited the growth of newly implanted as well as established MXT tumors when administered either by s.c. " 02/01/1984 - " Evidence indicates that synthetic estrogens do not cause tumors directly but can enhance the growth of neoplastic cells."

Related Drugs and Biologics

1.	Estrogens (Estrogen)
2.	Progestins (Progestagens)
3.	Hormones
4.	Conjugated (USP) Estrogens (Premarin)
5.	Diethylstilbestrol (Stilbestrol)
6.	Oral Contraceptives
7.	Estradiol (Estrace)
8.	DNA (Deoxyribonucleic Acid)
9.	Quinones
10.	Hexestrol

Related Therapies and Procedures

1.	Orchiectomy (Orchidectomy)
2.	Intramuscular Injections
3.	Injections
4.	Drug Therapy (Chemotherapy)