Phase II study of single intraperitoneal chemotherapy followed by systemic chemotherapy for gastric cancer with peritoneal metastasis.

Abstract

BACKGROUND:

We conducted a phase II study involving a single administration of intraperitoneal chemotherapy with paclitaxel followed by sequential systemic chemotherapy with S-1+ paclitaxel for advanced gastric cancer patients with peritoneal metastasis.

METHODS:

Gastric cancer patients with peritoneal metastasis were enrolled. Paclitaxel (80 mg/m(2)) was administered intraperitoneally at staging laparoscopy. Within 7 days, patients received systemic chemotherapy with S-1 (80 mg/m(2)/day on days 1-14) plus paclitaxel (50 mg/m(2) on days 1 and 8), followed by 7-days rest. The responders to this chemotherapy underwent second-look laparoscopy, and gastrectomy with D2 lymph node dissection was performed in patients when the disappearance of peritoneal metastasis had been confirmed. The primary endpoint of the study was overall survival rate.

RESULTS:

Thirty-five patients were enrolled. All patients were confirmed as having localized peritoneal metastasis by staging laparoscopy. Eventually, gastrectomy was performed in 22 patients. The median survival time of the total patient population and those patients in which gastrectomy was performed was 21.3 and 29.8 months, respectively. The overall response rate was 65.7 % for all patients. The frequent grade 3/4 toxic effects included neutropenia and leukopenia.

CONCLUSIONS:

Sequential intraperitoneal and intravenous paclitaxel plus S-1 was well tolerated in gastric cancer patients with peritoneal metastasis.

• Authors: Motohiro Imano, Atsushi Yasuda, Tatsuki Itoh, Takao Satou, Ying-Feng Peng, Hiroaki Kato, Masayuki Shinkai, Masahiro Tsubaki, Yasutaka Chiba, Takushi Yasuda, Haruhiko Imamoto, Shozo Nishida, Yoshifumi Takeyama, Kiyokata Okuno, Hiroshi Furukawa, Hitoshi Shiozaki
• Journal: Journal of gastrointestinal surgery : official journal of the Society for Surgery of the Alimentary Tract (J Gastrointest Surg) Vol. 16 Issue 12 Pg. 2190-6 (Dec 2012) ISSN: 1873-4626 [Electronic] United States
• PMID: 23099736 (Publication Type: Clinical Trial, Phase II, Journal Article)

Chemical References

• Antineoplastic Agents, Phytogenic
• Paclitaxel

Topics

• Adult
• Aged
• Antineoplastic Agents, Phytogenic (administration & dosage)
• Female
• Humans
• Instillation, Drug
• Male
• Middle Aged
• Paclitaxel (administration & dosage)
• Peritoneal Neoplasms (drug therapy, secondary)
• Peritoneum
• Prospective Studies
• Stomach Neoplasms (drug therapy, pathology)