Abstract | OBJECTIVE: DESIGN: A retrospective study. SETTING: A single center. PARTICIPANTS: INTERVENTION: MEASUREMENTS AND MAIN RESULTS: The hemodynamic profile was obtained before inhalation, during the administration of inhaled NO alone (prior and after iloprost), and after the first 2 doses of iloprost. Tricuspid annular velocity and tricuspid annular plane systolic excursion were estimated at baseline and before and after adding iloprost. At the end of the protocol, there were significant decreases in pulmonary vascular resistance (p < 0.001), the mean pulmonary arterial pressure (p < 0.001), and the mean pulmonary artery pressure/mean arterial pressure ratio (p = 0.006). Both tricuspid annular velocity (p < 0.001) and tricuspid annular plane systolic excursion (p < 0.001) increased. The cardiac index (p < 0.001) and venous blood oxygen saturation (p = 0.001) increased throughout the evaluation period. Each iloprost dose was associated with further decreases in pulmonary vascular resistances/pressure. By comparing data at the beginning of inhaled NO with those after the second dose of iloprost, the authors noticed decreases in pulmonary vascular resistances (p = 0.004) and the mean pulmonary artery pressure (p = 0.017) and rises in tricuspid annular velocity (p < 0.001) and tricuspid annular systolic plane systolic excursion (p < 0.001). CONCLUSIONS: Inhaled NO and iloprost significantly reduced pulmonary hypertension and contributed to the improvement in right ventricular function. Inhaled NO and iloprost have additive effects on pulmonary vasculature.
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Authors | Theofani Antoniou, Efstratios N Koletsis, Christos Prokakis, Panagiota Rellia, Apostolos Thanopoulos, Kassiani Theodoraki, Dimitrios Zarkalis, Petros Sfyrakis |
Journal | Journal of cardiothoracic and vascular anesthesia
(J Cardiothorac Vasc Anesth)
Vol. 27
Issue 3
Pg. 459-66
(Jun 2013)
ISSN: 1532-8422 [Electronic] United States |
PMID | 23063102
(Publication Type: Journal Article)
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Copyright | Copyright © 2013 Elsevier Inc. All rights reserved. |
Chemical References |
- Aerosols
- Vasodilator Agents
- Nitric Oxide
- Iloprost
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Topics |
- Aerosols
- Aged
- Arterial Pressure
(physiology)
- Cardiac Surgical Procedures
(methods)
- Electrocardiography
- Extracorporeal Circulation
- Female
- Heart Valves
(surgery)
- Hemodynamics
(drug effects)
- Humans
- Hypertension, Pulmonary
(drug therapy, physiopathology)
- Iloprost
(administration & dosage, therapeutic use)
- Male
- Middle Aged
- Nitric Oxide
(administration & dosage, therapeutic use)
- Risk
- Treatment Outcome
- Vascular Resistance
(physiology)
- Vasodilator Agents
(administration & dosage, therapeutic use)
- Ventricular Dysfunction, Right
(drug therapy, physiopathology)
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