Adrenaline promotes cell proliferation and increases chemoresistance in colon cancer HT29 cells through induction of miR-155.

Abstract

Recently, catecholamines have been described as being involved in the regulation of cancer genesis and progression. Here, we reported that adrenaline increased the cell proliferation and decreased the cisplatin induced apoptosis in HT29 cells. Further study found that adrenaline increased miR-155 expression in an NFκB dependent manner. HT29 cells overexpressing miR-155 had a higher cell growth rate and more resistance to cisplatin induced apoptosis. In contrast, HT29 cells overexpressing miR-155 inhibitor displayed decreased cell proliferation and sensitivity to cisplatin induced cell death. In summary, our study here revealed that adrenaline-NFκB-miR-155 pathway at least partially contributes to the psychological stress induced proliferation and chemoresistance in HT29 cells, shedding light on increasing the therapeutic strategies of cancer chemotherapy.

• Authors: Jun Pu, Danna Bai, Xia Yang, Xiaozhao Lu, Lijuan Xu, Jianguo Lu
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 428 Issue 2 Pg. 210-5 (Nov 16 2012) ISSN: 1090-2104 [Electronic] United States
• PMID: 23036199 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Inc. All rights reserved.

Chemical References

• Antineoplastic Agents
• MIRN155 microRNA, human
• MicroRNAs
• NF-kappa B
• Cisplatin
• Epinephrine

Topics

• Antineoplastic Agents (pharmacology)
• Cell Proliferation
• Cisplatin (pharmacology)
• Colonic Neoplasms (genetics, metabolism, pathology)
• Drug Resistance, Neoplasm
• Epinephrine (pharmacology, physiology)
• HT29 Cells
• Humans
• MicroRNAs (biosynthesis, genetics)
• NF-kappa B (metabolism)