Abstract | PURPOSE: METHODOLOGY: Thirty-three MM cases were treated with bisphosphonates (hereinafter called clodronate therapy group) and 20 MM cases were treated with simple chemotherapy (hereinafter called control group). uNTX and sBAP were tested during the courses of treatment three times (pretreatment, 3 months, and 6 months). uNTX was tested by enzyme-linked immunosorbent assay. sBAP was tested by chemiluminescence analysis. All the results were analyzed with t-test by using SPSS 11.0. RESULTS: There were no significant differences between therapy and control groups: in uNTX (173.74 ± 14.55) and (129.79 ± 12.13) μg/l before treatment (P > 0.05). After 6 months there were significant differences between them: (85.71 ± 8.23) and (121.59 ± 12.43) μg/l (P < 0.05). And also there were significant differences among the courses in the therapy group. There were no significant differences between therapy and control groups in sBAP concentration: (4.78 ± 0.55) and (8.42 ± 1.32) μg/l before treatment (P > 0.05). After 6 months there were significant differences between them: (16.01 ± 0.52) and (9.62 ± 1.29) μg/l (P < 0.001). And also there were significant differences among the courses in the therapy group. CONCLUSION: uNTX and sBAP were important to measure the situation of the osteolytic bone lesion in MM. Bisphosphonates can significantly reduce bone degradation and metabolism, improve the synthesis, which is valuable for the treatment of MM cases.
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Authors | Xi Zhang, Chunkang Chang, Youshan Zhao, Lingyun Wu, Zheng Zhang, Xiao Li |
Journal | Hematology (Amsterdam, Netherlands)
(Hematology)
Vol. 17
Issue 5
Pg. 255-60
(Sep 2012)
ISSN: 1607-8454 [Electronic] England |
PMID | 22971530
(Publication Type: Journal Article, Randomized Controlled Trial)
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Chemical References |
- Biomarkers, Tumor
- Bone Density Conservation Agents
- Collagen Type I
- Diphosphonates
- Peptides
- Alkaline Phosphatase
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Topics |
- Adult
- Aged
- Alkaline Phosphatase
(blood)
- Antineoplastic Combined Chemotherapy Protocols
(administration & dosage)
- Biomarkers, Tumor
(blood)
- Bone Density Conservation Agents
(administration & dosage)
- Bone Neoplasms
(blood, drug therapy, pathology, secondary)
- Collagen Type I
(blood)
- Diphosphonates
(administration & dosage)
- Female
- Humans
- Male
- Middle Aged
- Multiple Myeloma
(blood, drug therapy, pathology)
- Neoplasm Metastasis
- Osteolysis
(blood, drug therapy, pathology)
- Peptides
(blood)
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