Incidences of overall and site specific cancers in TNFα inhibitor treated patients with rheumatoid arthritis and other arthritides - a follow-up study from the DANBIO Registry.
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| Abstract | OBJECTIVES: To investigate the incidence of cancer in arthritis patients treated with or without TNFα inhibitors (TNF-I). METHODS:
Arthritis patients from the DANBIO database were followed-up for cancer in the Danish Cancer Registry during 2000-2008. RESULTS: Hazard ratio for cancer overall was 1.02 (95% confidence interval (CI) 0.80-1.30) in 3347 TNF-I-treated RA patients compared to non-treated. Excess among TNF-I-treated was found for colon cancer (HR 3.52 (95%CI 1.11-11.15), whereas 6 and 0 ovarian cancer cases were observed in treated and non-treated patients, respectively. Compared to the general population, TNF-I-treated RA patients had increased risk for cancer overall, cancer in lymphatic-haematopoietic tissue and non-melanoma skin cancer, while non-RA patients had no increase in overall cancer risk. CONCLUSIONS: Our results suggest that TNF-I therapy in routine care is not associated with an overall excess of cancer in arthritis patients, but observed increased risks of colon and ovarian cancer need further investigation.
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| Authors | Lene Dreyer, Lene Mellemkjær, Anne Rødgaard Andersen, Philip Bennett, Uta Engling Poulsen, Torkell Juulsgaard Ellingsen, Torben Høiland Hansen, Dorte Vendelbo Jensen, Louise Linde, Hanne Merete Lindegaard, Anne Gitte Rasmussen Loft, Henrik Nordin, Emina Omerovic, Claus Rasmussen, Annette Schlemmer, Ulrik Tarp, Merete Lund Hetland |
| Journal | Annals of the rheumatic diseases (Ann Rheum Dis) Vol. 72 Issue 1 Pg. 79-82 (Jan 2013) ISSN: 1468-2060 [Electronic] England |
| PMID | 22945500 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't) |
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