Ten-year outcomes of patients randomized to surgery, angioplasty, or medical treatment for stable multivessel coronary disease: effect of age in the Medicine, Angioplasty, or Surgery Study II trial.
Abstract | OBJECTIVE: METHODS: Patients were separated according to age: 65 years or more (n = 200) and less than 65 years (n = 411). All patients were followed for 10 years. The rates of overall mortality, acute myocardial infarction, and new revascularizations were analyzed. RESULTS: Of 200 patients aged 65 years or more, 68 were randomized to medical therapy, 68 were randomized to percutaneous coronary intervention, and 64 were randomized to coronary artery bypass grafting. At 10 years, overall survival was 63% (medical therapy), 69% ( percutaneous coronary intervention), and 66% ( coronary artery bypass grafting) (P = .93). The survival free of combined events was 43% (medical therapy), 38% ( percutaneous coronary intervention ), and 66% ( coronary artery bypass grafting) (P = .007). The survival free of myocardial infarction was 82% (medical therapy), 77% ( percutaneous coronary intervention), and 90% ( coronary artery bypass grafting) (P = .17), and survival free of new revascularizations was 59% (medical therapy), 58% ( percutaneous coronary intervention ), and 91% ( coronary artery bypass grafting) (P = .0003). When the 2 age groups were compared, survival free of myocardial infarction for patients treated by percutaneous coronary intervention was 77% (older patients) and 92% (younger patients) (P = .004). CONCLUSIONS:
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Authors | Paulo Cury Rezende, Whady Hueb, Cibele Larrosa Garzillo, Eduardo Gomes Lima, Alexandre Ciappina Hueb, José Antonio Franchini Ramires, Roberto Kalil Filho |
Journal | The Journal of thoracic and cardiovascular surgery
(J Thorac Cardiovasc Surg)
Vol. 146
Issue 5
Pg. 1105-12
(Nov 2013)
ISSN: 1097-685X [Electronic] United States |
PMID | 22944095
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2013 The American Association for Thoracic Surgery. Published by Mosby, Inc. All rights reserved. |
Chemical References |
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Topics |
- Age Factors
- Aged
- Angioplasty, Balloon, Coronary
(adverse effects, mortality)
- Brazil
- Cardiovascular Agents
(adverse effects, therapeutic use)
- Chi-Square Distribution
- Coronary Artery Bypass
(adverse effects, mortality)
- Coronary Artery Disease
(complications, diagnosis, mortality, therapy)
- Disease-Free Survival
- Female
- Humans
- Kaplan-Meier Estimate
- Male
- Multivariate Analysis
- Myocardial Infarction
(etiology, mortality, therapy)
- Proportional Hazards Models
- Prospective Studies
- Risk Factors
- Time Factors
- Treatment Outcome
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