Clinicopathologic characteristics and outcomes of surgery of middle-third gastric cancer.

Abstract

Many issues of middle-third gastric cancer need to be address for obtaining preferably clinical treatment. The objective of this retrospective study was to analyze clinicopathologic characteristics and results of surgery for 113 middle-third gastric cancer patients admitted to our hospital. Retrospective cohort analyses of clinicopathologic data and postoperative prognosis of 113 middle-third gastric cancer patients who underwent curative resection between January 1997 and December 2003 were reviewed. Compared with lower-third gastric cancer patients, middle-third gastric cancer patients had significantly lower 5-year survival rate (P < 0.001) and higher recurrence rate (P < 0.001). With the Cox proportional hazards model analysis, the types of gastrectomy (hazard ratio (HR) = 0.495, P = 0.012) and ratio between metastatic and dissected lymph nodes (RML) (HR = 1.681, P < 0.001) were identified as the independent predictors of overall survival (OS) of middle-third gastric cancer patients. Besides, only RML (HR = 3.026, P < 0.001) was an independent predictor of recurrence for middle-third gastric cancer patients after surgery identified using the logistic regression analysis. The prognosis of middle-third gastric cancer was significantly worse than lower-third gastric cancer. RML was a key indicator for OS and recurrence of middle-third gastric cancer.

• Authors: Jingyu Deng, Han Liang, Rupeng Zhang, Dan Sun, Yi Pan, Li Zhang, Xishan Hao
• Journal: Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine (Tumour Biol) Vol. 33 Issue 6 Pg. 2091-8 (Dec 2012) ISSN: 1423-0380 [Electronic] Netherlands
• PMID: 22869239 (Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)

Topics

• Aged
• Female
• Follow-Up Studies
• Gastrectomy (mortality)
• Humans
• Lymph Node Excision (mortality)
• Lymphatic Metastasis
• Male
• Middle Aged
• Neoplasm Recurrence, Local (mortality, pathology, surgery)
• Neoplasm Staging
• Peritoneal Neoplasms (mortality, secondary, surgery)
• Prognosis
• Retrospective Studies
• Stomach Neoplasms (mortality, pathology, surgery)
• Survival Rate