Abstract | BACKGROUND: METHODS AND RESULTS: A PubMed database search returned 27 studies on 16 cohorts reporting outcome and complications after ICD therapy in patients with hypertrophic cardiomyopathy. In case of >1 publications on a particular cohort, the publication with the largest number of patients was included in the meta-analysis. ICD interventions, complications, and mortality rates were extracted, pooled, and analyzed. There were 2190 patients (mean age, 42 years; 38% women), most of whom (83%) received an ICD for primary prevention of SCD. Risk factors for SCD were left ventricular wall thickness ≥30 mm (20%), family history of SCD (43%), nonsustained ventricular tachycardia (46%), syncope (41%), and abnormal blood pressure response (25%). During the 3.7-year follow-up, the annualized cardiac mortality rate was 0.6%, the noncardiac mortality rate was 0.4%, and the appropriate ICD intervention rate was 3.3%. The annualized inappropriate ICD intervention rate was 4.8% and the annualized ICD-related complication rate was 3.4%. CONCLUSIONS: This meta-analysis demonstrates a low cardiac and noncardiac mortality rate after ICD therapy in patients with hypertrophic cardiomyopathy. Appropriate ICD intervention occurred at a rate of 3.3%/year, thereby, most probably, preventing SCD. Inappropriate ICD intervention and complications are not uncommon.
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Authors | Arend F L Schinkel, Pieter A Vriesendorp, Eric J G Sijbrands, Luc J L M Jordaens, Folkert J ten Cate, Michelle Michels |
Journal | Circulation. Heart failure
(Circ Heart Fail)
Vol. 5
Issue 5
Pg. 552-9
(Sep 01 2012)
ISSN: 1941-3297 [Electronic] United States |
PMID | 22821634
(Publication Type: Journal Article, Meta-Analysis, Review, Systematic Review)
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Topics |
- Adolescent
- Adult
- Cardiomyopathy, Hypertrophic
(complications, mortality, therapy)
- Cause of Death
- Death, Sudden, Cardiac
(etiology, prevention & control)
- Defibrillators, Implantable
(adverse effects)
- Electric Countershock
(adverse effects, instrumentation, mortality)
- Female
- Humans
- Male
- Middle Aged
- Risk Assessment
- Risk Factors
- Time Factors
- Treatment Outcome
- Young Adult
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