Abstract | PURPOSE: METHODS: RESULTS: Of the 554 patients with stage I breast cancer, 78 (14.1%) had TNBC. A significant proportion of TNBC patients had histologic grade 3 tumors (47.4% vs. 34.5%, p=0.031) and tumors >1 cm (87.2% vs. 75.8%, p=0.028) and received adjuvant chemotherapy (79.5% vs. 44.7%, p<0.001). During a median follow-up time of 8.7 years, 72 patients experienced tumor recurrences; 18 (23.1%) in the TNBC group and 54 (11.3%) in the non-TNBC group (p=0.010), with cumulative 3-year rate of recurrence of 12.8% and 5.3%, respectively (p=0.010). Ten-year relapse-free survival (RFS; 75.6% vs. 87.5%, p=0.004) and overall survival (OS; 83.0% vs. 91.4%, p=0.002) rates were significantly lower in the TNBC group. Multivariate analysis showed that triple negativity and histologic grade were independent predictors of shorter RFS and OS. CONCLUSION: TNBC had more aggressive clinicopathologic characteristics and was associated with poorer survival in patients with stage I breast cancer. More intensive adjuvant chemotherapy or a different therapeutic strategy targeting this population is warranted.
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Authors | Jeong Eun Kim, Heui June Ahn, Jin-Hee Ahn, Dok Hyun Yoon, Sung-Bae Kim, Kyung Hae Jung, Gyung-Yub Gong, Mi-Jung Kim, Byung Ho Son, Sei Hyun Ahn |
Journal | Journal of breast cancer
(J Breast Cancer)
Vol. 15
Issue 2
Pg. 197-202
(Jun 2012)
ISSN: 2092-9900 [Electronic] Korea (South) |
PMID | 22807937
(Publication Type: Journal Article)
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