Preclinical testing of Peruvian anti-bothropic anti-venom against Bothrops andianus snake venom.

Abstract

Bothrops andianus is a venomous snake found in the area of Machu Picchu (Peru). Its venom is not included in the antigenic pool used for production of the Peruvian anti-bothropic anti-venom. B. andianus venom can elicit many biological effects such as hemorrhage, hemolysis, proteolytic activity and lethality. The Peruvian anti-bothropic anti-venom displays consistent cross-reactivity with B. andianus venom, by ELISA and Western Blotting and is also effective in neutralizing the venom's toxic activities.

• Authors: Francisco S Schneider, Maria C Starling, Clara G Duarte, Ricardo Machado de Avila, Evanguedes Kalapothakis, Walter Silva Suarez, Benigno Tintaya, Karin Flores Garrido, Silvia Seraylan Ormachea, Armando Yarleque, César Bonilla, Carlos Chávez-Olórtegui
• Journal: Toxicon : official journal of the International Society on Toxinology (Toxicon) Vol. 60 Issue 6 Pg. 1018-21 (Nov 2012) ISSN: 1879-3150 [Electronic] England
• PMID: 22796381 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Elsevier Ltd. All rights reserved.

Chemical References

• Antivenins
• Snake Venoms

Topics

• Animals
• Antivenins (pharmacology)
• Blotting, Western
• Bothrops
• Cross Reactions
• Drug Evaluation, Preclinical
• Enzyme-Linked Immunosorbent Assay
• Female
• Hemolysis (drug effects)
• Hemorrhage (physiopathology)
• Male
• Mice
• Peru
• Proteolysis (drug effects)
• Snake Venoms (chemistry)