Abstract | BACKGROUND: METHODS AND RESULTS: A total of 108 young men with Gilbert syndrome without cardiovascular risk factors and 108 age-matched healthy men (normal controls) were enrolled in this study. Serum concentrations of bilirubin were higher in patients with Gilbert syndrome than in control subjects (29.2±11.6 versus 9.4±2.7 μmol/L; P<0.001). Serum concentrations of malondialdehyde-modified low-density lipoprotein and urinary excretion of 8-hydroxy-2'-deoxyguanosine (8-OHdG), as indices of oxidative stress, were lower in patients with Gilbert syndrome than in control subjects (61.8±24.5 versus 72.5±21.8 U/L, P=0.034; 7.8±2.4 versus 10.4±3.2 ng/mg creatinine, P=0.001, respectively). Flow-mediated vasodilation was greater in patients with Gilbert syndrome than in normal control subjects (7.2±2.2% versus 5.9±1.7%; P<0.001). Vascular responses to nitroglycerine were not significantly different between the 2 groups. Flow-mediated vasodilation correlated with serum concentration of bilirubin (r=0.44, P<0.001), malondialdehyde-modified low-density lipoprotein (r=-0.25, P=0.01), and urinary excretion of 8-OHdG (r=-0.27, P=0.004) in patients with Gilbert syndrome but not in control subjects. In addition, serum concentration of bilirubin correlated with malondialdehyde-modified low-density lipoprotein (r=-0.20, P=0.04) and 8-OHdG (r=-0.21, P=0.02) in patients with Gilbert syndrome but not in control subjects. CONCLUSIONS: CLINICAL TRIAL REGISTRATION: URL: http://www.umin.ac.jp. Unique identifier: UMIN000003409.
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Authors | Tatsuya Maruhashi, Junko Soga, Noritaka Fujimura, Naomi Idei, Shinsuke Mikami, Yumiko Iwamoto, Masato Kajikawa, Takeshi Matsumoto, Yasuki Kihara, Kazuaki Chayama, Kensuke Noma, Ayumu Nakashima, Hirofumi Tomiyama, Bonpei Takase, Akira Yamashina, Yukihito Higashi |
Journal | Circulation
(Circulation)
Vol. 126
Issue 5
Pg. 598-603
(Jul 31 2012)
ISSN: 1524-4539 [Electronic] United States |
PMID | 22773454
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Chemical References |
- Lipoproteins, LDL
- 8-Hydroxy-2'-Deoxyguanosine
- Nitroglycerin
- Deoxyguanosine
- Bilirubin
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Topics |
- 8-Hydroxy-2'-Deoxyguanosine
- Adult
- Bilirubin
(blood)
- Brachial Artery
(physiology)
- Case-Control Studies
- Deoxyguanosine
(analogs & derivatives, urine)
- Endothelium, Vascular
(physiology)
- Gilbert Disease
(blood, physiopathology)
- Humans
- Hyperbilirubinemia
(blood, physiopathology)
- Lipoproteins, LDL
(blood)
- Male
- Nitroglycerin
(pharmacology)
- Oxidative Stress
(physiology)
- Regional Blood Flow
(physiology)
- Vasodilation
(drug effects, physiology)
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