Abstract | BACKGROUND: Women with germ line BRCA1 or BRCA2 mutations have a marked increased risk of breast and ovarian cancer compared with the general population, whereas risk-reducing salpingo-oophorectomy (RRSO) significantly lowers the incidence of these cancers. The objective of this study was to review the clinical and pathological characteristics of a French Canadian population undergoing RRSO. Surgical morbidity was also evaluated. MATERIALS AND METHODS: From December 1999 to December 2009, all women who underwent RRSO at our institution were identified. Medical records were retrospectively reviewed. Descriptive statistics, the Fischer exact test, and the Student t test were used for analysis. RESULTS: During the study period, RRSO was performed on 119 women. Mean age at surgery was 49 years (35-72 years), and 63 patients (53%) were premenopausal. Sixty-two women (52%) had a history of in situ or invasive breast cancer. BRCA1 and BRCA2 mutations were present in 34 patients (29%) and 42 patients (35%), respectively, whereas 43 patients (36%) were considered to have an increased risk of breast and ovarian cancer, despite a personal genetic test, which was either negative (n = 23) or unknown because the patient declined genetic testing (n = 20). Most patients with a uterus in place had a complementary hysterectomy (65%). Six complications occurred (3 hematomas, 2 cardiac arrhythmias, and 1 cystotomy). In one patient (0.8%), a high-grade stage II ovarian cancer was discovered at the time of surgery. Fallopian tube atypias were identified on final pathology in 8 cases (6.7%). After a median follow-up of 22 months, 4 women (3.4%) developed breast cancer and one woman (0.8%) developed peritoneal cancer. CONCLUSIONS: Risk-reducing salpingo-oophorectomy is highly effective in preventing ovarian, fallopian tube, and breast cancers in a high-risk French Canadian population; and the surgical morbidity is low.
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Authors | Omar Moreira Bacha, Jean Gregoire, Katherine Grondin, Maria Isabel Edelweiss, Rachel Laframboise, Jacques Simard, Marie Plante |
Journal | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society
(Int J Gynecol Cancer)
Vol. 22
Issue 6
Pg. 974-8
(Jul 2012)
ISSN: 1525-1438 [Electronic] England |
PMID | 22740003
(Publication Type: Journal Article)
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Topics |
- Adult
- Aged
- Canada
(epidemiology)
- Female
- Genes, BRCA1
- Genes, BRCA2
- Humans
- Middle Aged
- Ovarian Neoplasms
(ethnology, genetics, prevention & control)
- Ovariectomy
(statistics & numerical data)
- Ovary
(pathology)
- Retrospective Studies
- Salpingectomy
(statistics & numerical data)
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