[Pharmacological correction of toxic liver damage in patients with heavy forms of acute ethanol intoxication].

Abstract

The efficiency of using remaxol and ademethionine in the therapy of patients with heavy acute alcohol intoxication on the background of toxic liver damage has been studied. The administration of remaxol led to improvement of the clinical treatment of alcohol intoxication, which is manifested by a decrease in the rate and duration of delirium tremens (from 33.9 to 10.8%), frequency of secondary lung disorders (from 18.5 to 3.1%), duration of stay in hospital (from 7.3 +/- 0.6 to 5.6 +/- 0.3 days), and total therapy duration (from 11.8 +/- 1.05 to 5.6 +/- 0.3 days). The results of biochemical investigations confirmed that remaxol and ademethionine provide effective treatment of the toxic liver damage. Remaxol decreases the degree of metabolic disorders to a greater extent than does ademethionine.

• Authors: I A Shikalova, V V Shilov, S A Vasil'ev, B V Batotsyrenov, A T Loladze
• Journal: Eksperimental'naia i klinicheskaia farmakologiia (Eksp Klin Farmakol) Vol. 75 Issue 4 Pg. 30-3 ( 2012) ISSN: 0869-2092 [Print] Russia (Federation)
• PMID: 22702109 (Publication Type: Journal Article)

Chemical References

• Central Nervous System Depressants
• Remaxol
• Succinates
• Ethanol

Topics

• Acute Disease
• Adult
• Alcohol Withdrawal Delirium (drug therapy)
• Alcoholic Intoxication (drug therapy)
• Central Nervous System Depressants (adverse effects)
• Chemical and Drug Induced Liver Injury (drug therapy)
• Ethanol (adverse effects)
• Female
• Humans
• Male
• Middle Aged
• Succinates (administration & dosage)