Down-regulated miR-625 suppresses invasion and metastasis of gastric cancer by targeting ILK.

Abstract

Accumulating evidence has shown that microRNAs are involved in multiple processes in cancer development and progression. Here, we report that expression of miR-625 is significantly down-regulated and negatively correlated with lymph node metastasis in gastric cancer. miR-625 significantly inhibits invasion and metastasis of gastric cancer cells both in vitro and in vivo. Moreover, we identify that ILK is a direct target gene for miR-625 and knockdown of ILK has a phenocopy of overexpression of miR-625. Taken together, our findings suggest that miR-625 plays an important role in the mechanism of tumor metastasis.

• Authors: Ming Wang, Chenglong Li, Hui Nie, Xin Lv, Ying Qu, Beiqin Yu, Liping Su, Jianfang Li, Xuehua Chen, Jingfang Ju, Yingyan Yu, Min Yan, Qinlong Gu, Zhenggang Zhu, Bingya Liu
• Journal: FEBS letters (FEBS Lett) Vol. 586 Issue 16 Pg. 2382-8 (Jul 30 2012) ISSN: 1873-3468 [Electronic] England
• PMID: 22677169 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Chemical References

• 3' Untranslated Regions
• MIRN625 microRNA, human
• MIRN625 microRNA, mouse
• MicroRNAs
• integrin-linked kinase
• Protein Serine-Threonine Kinases

Topics

• 3' Untranslated Regions
• Aged
• Animals
• Cell Line, Tumor
• Cell Movement
• Down-Regulation
• Female
• Gene Expression Regulation, Neoplastic
• HEK293 Cells
• Humans
• Lymphatic Metastasis
• Male
• Mice
• Mice, Nude
• MicroRNAs (biosynthesis, metabolism)
• Middle Aged
• Neoplasm Invasiveness
• Neoplasm Metastasis
• Protein Serine-Threonine Kinases (metabolism)
• Stomach Neoplasms (metabolism, pathology)
• Transfection
• Wound Healing