Abstract | INTRODUCTION: AREAS COVERED: This review is based upon a PubMed search and personal experience with nalfurafine hydrochloride. The pharmacokinetics and pharmacodynamics of nalfurafine hydrochloride are reviewed and its efficiency and potential adverse effects are discussed, mainly based on the findings of randomized controlled trials. EXPERT OPINION: A recent long-term open trial showed that the effect of nalfurafine hydrochloride was enhanced by continuous, long-term administration. It will be of future interest to investigate its effect on excoriations, lichen simplex, prurigo nodularis and acquired perforating dermatosis (all caused by uremic pruritus), because it targets both the skin and the central nervous system. In clinical practice, it should be kept in mind that basic skin care with emollients and other topical drugs is essential for stopping the itch-scratch cycle, and the resultant skin barrier dysfunction.
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Authors | Shigeki Inui |
Journal | Expert opinion on pharmacotherapy
(Expert Opin Pharmacother)
Vol. 13
Issue 10
Pg. 1507-13
(Jul 2012)
ISSN: 1744-7666 [Electronic] England |
PMID | 22663138
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
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Chemical References |
- Dermatologic Agents
- Morphinans
- Receptors, Opioid, kappa
- Spiro Compounds
- TRK 820
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Topics |
- Dermatologic Agents
(pharmacokinetics, pharmacology, therapeutic use)
- Humans
- Morphinans
(pharmacokinetics, pharmacology, therapeutic use)
- Pruritus
(drug therapy)
- Receptors, Opioid, kappa
(agonists)
- Spiro Compounds
(pharmacokinetics, pharmacology, therapeutic use)
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