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The power and pitfalls of IL-12.

Abstract
In this issue of Blood, Pegram and colleagues describe the ability to improve adoptive T-cell therapies by engineering T cells to secrete the potent proinflammatory cytokine IL-12.1 These exciting findings significantly extend previous observations made in a murine melanoma model targeting naturally occurring tumor antigens.2,3
AuthorsSid P Kerkar, Nicholas P Restifo
JournalBlood (Blood) Vol. 119 Issue 18 Pg. 4096-7 (May 03 2012) ISSN: 1528-0020 [Electronic] United States
PMID22555659 (Publication Type: Comment, Journal Article)

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