Abstract | UNLABELLED: Encapsulated papillary carcinoma ( EPC) of the breast is a distinct histological subtype characterised by malignant epithelial proliferation supported by fibrovascular stalks. Although EPC typically lacks myoepithelial cells, it shows indolent clinical course. The classification of EPC as an in situ, or invasive disease, remains a matter of debate. METHODS: RESULTS:
EPC showed higher expression levels of both MMP-1 and MMP-9 compared with DCIS, and no significant differences were observed between EPC and invasive carcinoma. Expression of MMP-2 and MMP-7 levels were similar in EPC and DCIS, but both showed lower levels compared with invasive tumours. EPC showed higher expression of E-cadherin and transforming growth factor receptor ß1 compared with both DCIS and invasive cancer. No difference in the stromal expression of MMPs or tumour expression of VEGF was detected. CONCLUSION:
EPC exhibits an expression pattern of invasion-associated markers, which is intermediate in nature between DCIS and invasive cancer, providing further support of the unique biological features of EPC, and which may explain its clinically indolent behaviour.
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Authors | Emad A Rakha, May Tun, Enaam Junainah, Ian O Ellis, Andrew Green |
Journal | Journal of clinical pathology
(J Clin Pathol)
Vol. 65
Issue 8
Pg. 710-4
(Aug 2012)
ISSN: 1472-4146 [Electronic] England |
PMID | 22554960
(Publication Type: Journal Article)
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Chemical References |
- Antigens, CD
- Biomarkers, Tumor
- CDH1 protein, human
- Cadherins
- Receptors, Transforming Growth Factor beta
- VEGFA protein, human
- Vascular Endothelial Growth Factor A
- Protein Serine-Threonine Kinases
- Receptor, Transforming Growth Factor-beta Type I
- MMP7 protein, human
- Matrix Metalloproteinase 7
- MMP2 protein, human
- Matrix Metalloproteinase 2
- Matrix Metalloproteinase 9
- MMP1 protein, human
- Matrix Metalloproteinase 1
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Topics |
- Antigens, CD
- Biomarkers, Tumor
(analysis)
- Breast Neoplasms
(chemistry, pathology)
- Cadherins
(analysis)
- Carcinoma, Intraductal, Noninfiltrating
(chemistry, pathology)
- Carcinoma, Papillary
(chemistry, pathology)
- Chi-Square Distribution
- England
- Female
- Humans
- Immunohistochemistry
- Matrix Metalloproteinase 1
(analysis)
- Matrix Metalloproteinase 2
(analysis)
- Matrix Metalloproteinase 7
(analysis)
- Matrix Metalloproteinase 9
(analysis)
- Neoplasm Invasiveness
- Prognosis
- Protein Serine-Threonine Kinases
(analysis)
- Receptor, Transforming Growth Factor-beta Type I
- Receptors, Transforming Growth Factor beta
(analysis)
- Retrospective Studies
- Stromal Cells
(chemistry, pathology)
- Tissue Array Analysis
- Vascular Endothelial Growth Factor A
(analysis)
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