[Comparisons of efficacy of different pulmonary surfactants for the treatment of neonatal respiratory distress syndrome].

Abstract

OBJECTIVE:

To compare the clinical efficacy of imported pulmonary surfactant (PS) pig lung phospholipids injection (pig PS) and domestic cattle lung surface-active agent (cattle PS) for the treatment of neonatal respiratory distress syndrome (NRDS).

METHODS:

A total of 180 cases of grade IV NRDS receiving pig PS (n=90) or cattle PS treatment (n=90) were enrolled. The blood gas analysis and chest X-ray results and the incidence of complications after treatment, and hospitalization time and cost were compared between the two treatment groups.

RESULTS:

The efficiency rate in the pig PS group (97%) was higher than in the catle PS group (83%) (P<0.01). The cure rate in the pig PS group was also higher than in the cattle PS group (84% vs 66%; P<0.01). The incidence of pneumothorax in the pig PS group was lower than in the cattle PS group (3% vs 7%; P<0.05). The hospitalization time in the pig PS group was shorter than in the cattle PS group (21 ± 4 days vs 23 ± 4 days; P<0.05). There were no significant differences in the total hospitalization cost between the two groups.

CONCLUSIONS:

Pig PS seems to be superior to cattle PS in the treatment of grade IV NRDS.

• Authors: Yun Liu, Li Li, Wen-Ying Liang, Chun-Xia Nie
• Journal: Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics (Zhongguo Dang Dai Er Ke Za Zhi) Vol. 14 Issue 4 Pg. 253-5 (Apr 2012) ISSN: 1008-8830 [Print] China
• PMID: 22537950 (Publication Type: Comparative Study, English Abstract, Journal Article)

Chemical References

• Pulmonary Surfactants

Topics

• Animals
• Blood Gas Analysis
• Cattle
• Female
• Hospitalization (economics)
• Humans
• Infant, Newborn
• Length of Stay
• Male
• Pulmonary Surfactants (therapeutic use)
• Respiratory Distress Syndrome, Newborn (complications, drug therapy)
• Swine