In vivo NIRF imaging of tumor targetability of nanosized liposomes in tumor-bearing mice.

Abstract

To optimize tumor targetability of nanosized liposomes for application as drug carriers, various liposomes are prepared by incorporating different amounts (10, 30, and 50 wt%) of cationic, anionic, and PEGylated lipids into neutral lipid. In vivo near-infrared fluorescence images reveal that PEG-PE/PC liposomes display high tumor accumulation in tumor-bearing mice, while large amounts of DOTAP/PC liposomes are rapidly captured in the liver, resulting in poor tumor accumulation. These results demonstrate that optimization of the surface properties of liposomes is very important for their tumor targetability, and that in vivo imaging techniques are useful in developing and optimizing nanosized liposome-based drug carriers.

• Authors: Sangmin Lee, Seung-Young Lee, Sangjin Park, Ju Hee Ryu, Jin Hee Na, Heebeom Koo, Kyung Eun Lee, Hyesung Jeon, Ick Chan Kwon, Kwangmeyung Kim, Seo Young Jeong
• Journal: Macromolecular bioscience (Macromol Biosci) Vol. 12 Issue 6 Pg. 849-56 (Jun 2012) ISSN: 1616-5195 [Electronic] Germany
• PMID: 22535787 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Chemical References

• Fatty Acids, Monounsaturated
• Liposomes
• Quaternary Ammonium Compounds
• 1,2-dioleoyloxy-3-(trimethylammonium)propane

Topics

• Animals
• Drug Delivery Systems (methods)
• Fatty Acids, Monounsaturated (chemistry, pharmacology)
• Fluorescence
• HeLa Cells
• Humans
• Liposomes
• Male
• Mice
• Mice, Nude
• Microscopy, Fluorescence (methods)
• Nanoparticles (chemistry)
• Neoplasms, Experimental (pathology, ultrastructure)
• Quaternary Ammonium Compounds (chemistry, pharmacology)
• Surface Properties