Prognostic significance of NANOG and KLF4 for breast cancer.

Abstract

BACKGROUND:

Some of the induced pluripotent stem cell (iPS cell)-inducing factors have been reported to be expressed in breast cancer. The aim of the present study was to examine the relationship between the expression of iPS cell-inducing factors and the prognosis of breast cancer patients.

METHODS:

In 100 breast cancer patients, the expression of c-MYC, KLF4, NANOG, OCT4, and SOX2 was determined by immunohistochemistry using a tissue microarray analysis.

RESULTS:

Patients with strong expression of NANOG had significantly lower disease-free survival (DFS) and overall survival rates than those with weak expression of NANOG (P = 0.004 and 0.033, respectively). In contrast, patients with strong expression of KLF4 had better DFS (P = 0.014).

CONCLUSIONS:

Strong expression of NANOG is an indicator of a poor prognosis for breast cancer patients, whereas KLF4 is a favorable prognostic indicator. Our results suggest that NANOG stimulates the growth and metastasis of breast cancer cells, whereas KLF4 inhibits these processes.

• Authors: Takuya Nagata, Yutaka Shimada, Shinichi Sekine, Ryota Hori, Koshi Matsui, Tomoyuki Okumura, Shigeaki Sawada, Junya Fukuoka, Kazuhiro Tsukada
• Journal: Breast cancer (Tokyo, Japan) (Breast Cancer) Vol. 21 Issue 1 Pg. 96-101 (Jan 2014) ISSN: 1880-4233 [Electronic] Japan
• PMID: 22528804 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Biomarkers, Tumor
• Homeodomain Proteins
• KLF4 protein, human
• Kruppel-Like Factor 4
• Kruppel-Like Transcription Factors
• MYC protein, human
• NANOG protein, human
• Nanog Homeobox Protein
• Octamer Transcription Factor-3
• POU5F1 protein, human
• Proto-Oncogene Proteins c-myc
• SOX2 protein, human
• SOXB1 Transcription Factors

Topics

• Adult
• Aged
• Aged, 80 and over
• Biomarkers, Tumor (metabolism)
• Breast Neoplasms (metabolism, mortality, pathology, surgery)
• Disease-Free Survival
• Female
• Homeodomain Proteins (metabolism)
• Humans
• Kruppel-Like Factor 4
• Kruppel-Like Transcription Factors (metabolism)
• Middle Aged
• Nanog Homeobox Protein
• Octamer Transcription Factor-3 (metabolism)
• Predictive Value of Tests
• Prognosis
• Proto-Oncogene Proteins c-myc (metabolism)
• SOXB1 Transcription Factors (metabolism)