Abstract | BACKGROUND: METHODS: Between the years 2003 and 2011 we measured NT-proBNP in consecutive ACHD patients attending the outpatient department. Further NT-proBNP analysis was performed on 705 blood samples from 394 stable patients with the defect corrected. The results were compared among different diagnostic groups and with a control group of healthy volunteers. RESULTS: The median value of NT-proBNP in the whole cohort was signifinatly higher than in the control group (211 vs 42 pg/mL; P < 0.0001). The median value of NT-proBNP in pg/mL and the percentage of normal NT-proBNP values in the listed diagnostic groups were as follows: coarctation of the aorta ( COA), 97 (64%); pulmonary stenosis (PS),160 (48%); secundum atrial septal defect (ASD), 254 (44%); incomplete atrioventricular septal defect ( AVSD), 211 (32%); ventricular septal defect (VSD), 154 (58%); tetralogy of Fallot (TOF), 177 (38%); transposition of the great arteries (TGA) after Mustard, 237 (20%) or Senning correction, 143 (39%); Ebstein anomaly 287, (26%); pulmonary atresia (PA), 327 (18%); and complex defects after Fontan procedure, 184 (31%). CONCLUSIONS:
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Authors | Jana Popelová, Karel Kotaška, Stěpán Černý, Milena Prokopová, Miroslav Rubáček |
Journal | The Canadian journal of cardiology
(Can J Cardiol)
2012 Jul-Aug
Vol. 28
Issue 4
Pg. 471-6
ISSN: 1916-7075 [Electronic] England |
PMID | 22482396
(Publication Type: Comparative Study, Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2012 Canadian Cardiovascular Society. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Peptide Fragments
- pro-brain natriuretic peptide (1-76)
- Natriuretic Peptide, Brain
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Topics |
- Adult
- Female
- Follow-Up Studies
- Heart Defects, Congenital
(blood, diagnosis, surgery)
- Humans
- Male
- Middle Aged
- Natriuretic Peptide, Brain
(blood)
- Peptide Fragments
(blood)
- Postoperative Complications
(blood)
- Reference Values
- Young Adult
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